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Conformation of lipid, DSPC and cholesterol mixture
In this proposal we intend to investigate the intermolecular interactions in a mixed phospholipid/cholesterol monolayer at the oil-water interface using neutron reflectometry.... -
Neutron reflectivity study of bacterial lipopolysaccharide interactions with ...
Bacterial LPS (endotoxin) is a key determinant of host/pathogen interactions. We propose to investigate the role of membrane lateral phase separation on LPS insertion into model... -
Probing the internal structure of gene delivery vehicles using contrast varia...
Gene delivery vehicles, known as LPD complexes, prepared from mixing cationic lipid vesicles (L) with cationic peptide (P) and DNA (D) have proven to be very effective at... -
Structural study on the 3D arrangement of (hexa-acyl) lipid A in lipid membrane
Lipopolysaccharides are amphiphilic macromolecules indispensable for the growth and the survival of Gram-negative bacteria, one of the most diffuse classes of pathogenic... -
Measuring phospholipid flip-flop rates across vesicle bilayers
Asymmetry across biological membranes is vital for a wide range of organelle and cellular functions. Significant differences in lipid composition have been found between the... -
Study of the role of penetration enhancer for drug delivery through Stratum C...
The stratum corneum which is mainly composed of mixture of lipids, cholesterols and fatty provide a formidable barrier for drug penetration through skin. In this proposal, we... -
Influence of polymer molecular weight on polymer stabilized lipid nanodiscs
Nanostructured lipid aggregates offer enormous potential as tools for membrane structural biology and biophysics. Poly(Styrene-Maleic Acid) stabilized lipid nanodiscs have a... -
Interaction of lamellar and non-lamellar lipid mesophases with inorganic nano...
The behavior of inorganic nanoparticles (NPs) with biological interfaces is a key research topic, to boost Nanomedicine development. In this respect, 2D lipid assemblies are... -
Neutron Reflectivity study of lipopolysaccharide complexes with lateral domai...
We propose to investigate the role of lateral phase separation on LPS insertion into model membranes and the effects of target membrane structure and composition. A comparison... -
Selective recruitment of cholesterol to lipid rafts by multivalent protein bi...
Lipid raft microdomains offer a means to enhance the local concentration of membrane components as well as serve as a platform for raft associated endocytosis. Driven by... -
Study of the interaction of thermoresponsive nanogels with model skin
Skin is an important site for drug delivery. However skin, the stratum corneum which is mainly composed of mixture of lipids, cholesterols and fatty provide a barrier for drug... -
The structure of mucin at large distances - a spin-echo SANS study
Mucus is a bio-gel, an opaque and slimy secretion that forms a continuous ¿blanket¿ adherent to epithelial surfaces in mammalian organs (eye, nose, conductive airways,... -
Exploratory SERGIS/SESANS study of Si nanowires
Nanowires are increasingly being used in life science as nanometer probes and interfacing with cells. In our work we focus on the interaction between nanowires and a... -
Structure and thermodynamics of polyethylene glycol chusions
A long term goal for biophysical studies has been to fabricate bio-membranes on solid supports. A highly hydrated ¿cushion¿ between the membrane and the underlying support can... -
The role of tryptophan in puroindoline/purothionin cooperative binding to bio...
The puroindoline (PIN) and purothionin (PTH) families of polypeptides both occur in wheat and are implicated in antipathogenic defence mechanisms, and of interest for potential... -
Conformational analysis of subtilin / lipid II binary antibiotic/target membr...
Antibiotic resistance is pathogenic bacteria is a major clinical problem. Resistance to all antibiotiotic classes, currentl yin clinical use, has been reported. By contrast, the... -
Is cloud water nitrate radical chemistry important in oxidising thin films on...
Projected climate change is strongly influenced by clouds. The oxidative processing of pollutants in clouds affects droplet size and reflectivity, important climatic effects.... -
Structure of siRNA containing delivery vehicles: effect of serum
Complexes prepared from cationic, dichain lipid (L) vesicles and negatively charged siRNA (R), with and without positively chargely targeting peptides (P) known as LR or LPR... -
Investigating the response of lipid bilayers to physically structured substrates
The functionality of biological membranes is closely tied to their structural behavior. To understand this behavior we propose to study the conformality of artificial lipid... -
Probing the structure/function relationship of NhaA protein incorporated into...
We propose to perform combined measurements of neutron reflectometry (NR) and impedance spectroscopy (IS) to investigate the structure/function relationship of tethered bilayer...