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Temperature driven self-assembly of amphiphilic block copolymers in water.
Amphiphilic copolymers with perfluoroalkyl blocks provide self-assembled nanostructures, in water, via the association and/or self-folding of the copolymer chains. This feature... -
SANS evaluation of novel nanocolloidal drug carriers
With the beamtime requested we plan to employ small-angle neutron scattering (SANS) to study novel nanocolloidal drug carriers prepared using lipids, surfactants and... -
Solubilisation in Zwitterionic Micelles: Effect of Structure
The project aims to probe the relationship between surfactant structure, the micelles formed in solution, and the type of drug molecules that the micelles solubilise. Once... -
Structural and mechanistic study of nanocapsule / hydrogel composites for dru...
The targeted delivery of non-water soluble drugs for applications such as cancer remains a major challenge. Nanocapsules are new materials that can act as a depot for such drugs... -
The effect of particles on the structure of mucin ¿understanding the challeng...
Progress in the development of nano-sized hybrid therapeutics and nano-sized drug delivery systems - "nanomedicines" - over the last decade has been remarkable. One key... -
Aggregation behaviour of aqueous hairy rod conjugated polyelectrolyte/surfact...
Small angle neutron scattering (SANS) will be used to characterise the structures of aggregates formed between the anionic conjugated polyelectrolyte... -
Responsive polymer brushes grafted from gold nanoparticles: interaction with ...
We will use SANS to characterize dispersions of gold nanoparticles functionalized with poly(dimethyl aminoethyl methacrylate) brushes grafted from 25 nm gold nanoparticle... -
The mode of action of a novel disruptive antimicrobial technology on model me...
A Unilever proprietary technology has been shown to inhibit biofilm growth and development, and is also found to possess antimicrobial activity, effective both as a... -
Effect of shear and charged polymers on cellulose microfibrils
Cellulose is an important natural material used in many industrial applications, such as food and medicine. Cellulose micro-fibrils (CMF) are produced from wood, plants, and... -
SANS studies of mixed phsopholipid:sterol vesicles and their interaction with...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
Structure and mobility of surfactant additives in PDMS resin
Polysiloxane materials are commonly used in marine coatings due to their inherently low surface energy and flexibility which makes them suitable base materials for foul release... -
On the structure and composition of non-lamellar lipid-based liquid crystalli...
Liquid crystalline particles consisting of glycerol dioleate (GDO) / soy phosphatidylcholine (SPC) mixture and stabilised by polysorbate 80 (P80) have proven to be suitable as... -
SANS study of interaction of iron with alginate
Bowel cancer is the fourth most common cancer in the UK with approximately 41,000 individuals in the UK diagnosed annually. Importantly it is estimated that over half of all... -
Contrast matching of selectively deuterated glycerides for scattering studies...
Lipid nanoparticles (LNPs) can be formed from glycerides and loaded with diverse cargo for healthcare applications. A key advantage of LNPs over liposomes is the significant... -
Unlocking Structure-Property Relationships in Composite Semiconducting Nanopa...
Colloidal dispersions of organic semiconducting nanoparticles (NPs) have shown promise for the generation of active layers in organic solar cells.Composite NPs containing a... -
Conformation of thermo-responsive methacrylate based comb polymers in D2O sol...
A series of well defined comb polymers consisting of methacrylate backbones and oligo(2-ethyl-2-oxazoline) side chains was shown to exhibit lower critical solution temperature... -
Study of creep cavitation in pre-strained creep hourglass test specimens
Studies of creep behaviour in structures that operate at elevated temperatures such as nuclear power plants are important for structural integrity assessments. The effect of... -
Aggregation in ionic liquids
The aim of this experiment is to investigate surfactant aggregation in ionic liquids and also ionic liquid ¿ oil and ionic liquid ¿ water microemulsions via SANS. Contrast... -
Origin of co-nonsolvency, based on the Flory-Huggins interaction parameters o...
Co-solvency and Co-nonsolvency are two extreme phenomena in the field of polymer solution. The former is the phenomenon that a mixture of two nonsolvent forms a good solvent for... -
Worm-like reversed micelles with a CO2-philic surfactant
Hydrotropes (Figure 3 A-C) are known viscosifying agents with surfactants in organic solvents1 and interestingly now in supercritical CO2 (scCO2)5. The mechanism is...
