749 datasets found

Bacterial membranes contain safety valves called mechanosensitive ion channels, which protect the bacterium from changes in the osmotic pressure of their environment. However,...

The presence of lung surfactant at the air-water interface of the lung is vital to prevent alveolar collapse. Exposure to environmental pollutants can cause the formation of...

Tea-catechins differ in the molecular constitutions and stereochemistry, in-turn showing variance in their bioactivity and radical-scavenging potential. This evidences differing...

The glycosylation of glycoproteins is a major determinant of their stability, and glycans also affect their aggregatibility (precipitation). An understanding of this is...

Dioctadecyldimethylammonium bromide (DODAB), is a double chain synthetic cationic lipid that conforms the membrane-like bilayer structure and has found widespread use in several...

Bilayers which float below a self-assembled monolayer (SAM) coated solid support represent one of the most advanced membrane mimetics. Recently (RB 1720155) we assessed the...

The study of antifungal and antibacterial action is of great interest and there are still many unknowns concerning the action of membrane lytic materials, and the way that...

Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). The mitochondrial apoptotic pathway is a...

In this proposal we will study the structure of the myoglobin-trehalose-water system. It is well known that trehalose has an excellent cryo- and bioprotective role for...

Gram-negative bacteria, which cause a variety of diseases including meningitis, plague, sepsis and food poisoning, are becoming increasingly antibiotic resistant. One reason is...

Hydroxyl radicals may be used as disinfection agent in the advanced oxidation processes or tertiary treatment of waste and occasionally drinking water. We very recently oxidised...

Biosurfactants are becoming more commonplace in pharmaceuticals, vaccines and other forms of medicines. With the biobased economy growing substantially and pressure to reduce...

Understanding how nanoparticles interact with lipid bilayers will potentially have high impact on the development of new drug delivery systems, and on the investigation of their...

Plastic bags are used as containers for storage of donated blood. These bags are often made of PVC plasticized with dialkylphthalates (e.g. DEHP), which migrates into the blood...

Biosurfactants are becoming more commonplace in pharmaceuticals, vaccines and other forms of medicines. With the biobased economy growing substantially and pressure to reduce...

We will use SANS of emulsions in which the dispersed water droplets (<10 um diameter) are contrast matched to the continuous perdeuterated dodecane oil phase to measure the...

Deep Eutectic Solvents (DES) are molecular mixtures similar to ionic liquids, having melting points below room temperature. However instead of being composed of a salt, the...

We have recently used Polref in to measure the assembly of tethered floating lipid bilayers. These are useful models of biological membranes in which a phospholipid bilayer is...

Purothionins and defensins are basic, amphiphilic, cysteine-rich and low molecular weight plant defence proteins. These proteins are active against a broad range of...

Ultrasound is a very attractive and patient-friendly imaging technique, as it is easy to use, fast and non-invasive. Nevertheless, its use is severely limited by the low...