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An INS study of mono- and di-cationic phosphonium ionic liquids interacting w...
We propose to carry out Inelastic Neutron Scattering experiments to investigate the interaction of mono- and di-cationic phosphonium-based ionic liquids (IL's) with hydrated... -
Biosurfactant conventional surfactant mixing at the hydrophilic solid liquid ...
The biobased economy growing substantially and pressure to reduce reliance on palm and crude oil derived materials, demand that Home and Personal Care industries develops... -
Correlative Imaging of Plant Roots using X-rays and Neutrons
Recent advances in tomography have enabled sophisticated approaches to understanding soil and plant relations. The set of biophysicochemical processes occurring at the root/soil... -
Dynamics of a novel gadolinium lipid
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Interactions of lipidic cubic nanoparticles with model lipid biomembranes at ...
Lipidic cubic nanoparticles (LCNPs) have been extensively studied as therapeutic agents and delivery systems due to their biocompatibility, ease of drug encapsulation and... -
New Approaches to Producing Floating Supported Bilayers
The complex sample environment needed for floating supported bilayers has often led to a need to constantly redevelop the system to improve reproducibility. Here we plan to... -
Purothionin binding to model fungal lipid membranes
Purothionins and defensins are basic, amphiphilic, cysteine-rich and low molecular weight plant defence proteins. These proteins are active against a broad range of... -
SANS study of lipid-based nanocarriers as inhaled drug delivery systems for a...
The present project aims to achieve a more detailed structural characterization by SANS of Solid Lipid Nanoparticles (SLN) and liposomes in a perspective of an inhaled anti... -
Testing the Validity of Models to Describe the Protein Dynamics from EFWS data
Zaccai et al. proposed to build up a neutron Dynamics Data Bank which would be populated with dynamical data of biological macromolecules measured with different techniques,... -
Examining the conformation and orientation of an IgG-4 in complex with immobi...
Objectives of this proposal aim to shed light on how adsorption processes such as protein A chromatography, used to purify biologics, affect protein propensity for aggregation.... -
Structural studies on drugs and lipids in amphiphilic solutions
How drugs cross the formidable blood brain barrier in order to function is not well understood, specifically with respect to the interplay between hydrophobic and hydrophilic... -
Antimicrobial peptide-loaded nanogels and their interaction with lipid bilayers
Due to increasing antibiotic resistance, bacteria membrane disrupting antimicrobial peptides (AMPs) are of increasing interest as alternatives to classical antibiotics. AMPs are... -
Mimicking Pathogens : Floating Gram Negative Bacterial Membranes Containing t...
Recently we have been able to show two advances in the creation of realistic models of the Gram negative bacterial outer surface for use in biophysical and structural studies.... -
Conformational changes of human growth hormone driven by the interaction with...
The tale of protein-surfactant interactions has been the goal of many scientific investigations in the last few decades. The interaction between proteins and amphiphiles in... -
Copy of: The Mechanism of Bam Mediated Outer Membrane Protein Folding
The proteins of the outer membrane of Gram-negative bacteria are critical for bacterial survival,from providing basic physiological functions, to impairing virulence and... -
Structure of Confined Mucin Films
Nowadays, a significant research effort is devoted to understand and mimic biological lubricants which, in contrast to most man-made lubricants, are based on water. It has been... -
PROBING DRUG PHARMACODYNAMICS BY QENS: THE EFFECT OF CISPLATIN-LIKE ANTICANCE...
Water supports vital biochemical processes in living organisms, namely through maintenance of the three-dimensional architecture of biopolymers by a tight interplay with their... -
The origins of surface activity in naturally occurring surfactants
The biobased economy growing substantially and pressure to reduce reliance on palm and crude oil derived materials, demand that Home and Personal Care industries develops... -
Effect of glycolipids with therapeutic potential on phase behaviour of model ...
alpha-galactosylceramide (a-GalCer) can activate an immune response through a protein-mediated cell signalling event. The effect of a-GalCer on local membrane structure is... -
Short peptide self-assembly and pesticide solubilisation in binary surfactant...
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