56 datasets found

This proposal seeks to gain an understanding of the adsorption and desorption behaviour of a redox membrane protein, cytochrome c, in electrochemical cells using different anode...

Lipopeptide surfactants are highly effective at reducing interfacial tension. However, there is a general lack of understanding of the relationship between their molecular...

Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). The mitochondrial apoptotic pathway is a...

We are unravelling the solution structures of the Fab and Fc fragments in the IgA antibody family important in mucosal immunology. Having completed the structures for IgA...

Lipopeptide surfactants are highly effective at reducing interfacial tension. However, there is a general lack of understanding of the relationship between their molecular...

Aggregates of the cationic conjugated polyelectrolyte (CPE) HTMA-PFP with poly(vinyl alcohol) (PVA) will be studied in aqueous solutions using SANS. Previous fluorescence,...

Cyclic peptide-polymer conjugates can readily self-assembly into long nanotubes, and are being extensively studied for drug delivery applications. Recently, using SANS and...

Controlled vesicle fusion has major advantages in diagnostic and drug delivery applications. We have designed a DNA hybridisation-based assay for directed fusion of vesicles...

Water dynamics plays a vital role in biochemical processes in a living organism. Intracellular water structure and dynamics are known to be changed by the presence of...

Of concern to the bioprocessing industry is the manner in which polysorbates included in solution formulations of antibodies affect the kinetics and equilibrium state of...

In the proposed experiments we aim to characterise the structures of aggregate species formed when divalent metal ions, such as calcium(II), interact with the anionic conjugated...

Many biological processes occur at the interface of cells, at the so called cell membrane, such as internalization of biological nanoparticles, including virions, exosomes and...

This proposal is about the development of sustainable detergency based formulations, based on the blending of biosurfactants with conventional surfactants, and is part of a CASE...

Cell adhesion and proliferation at the surface of liquids such as oil droplets is a surprising phenomenon as it is typically accepted in the field of bioengineering that cells...

Exposure to ozone gas can cause inflammation of the airways and breathing difficulties. The initial reaction of ozone is thought to be predominantly with lipids present in the...

Abnormally glycosylated IgA leads to IgA nephropathy, the most common cause of renal failure. IgG antibody represents one-third of new drugs currently in development, and its...

Within a biological system such as a cell or tissue, water structure and dynamics are known to be changed by the presence of biomolecules or extrinsic entities (e.g. drugs),...

In this work, we propose to exploit the unique capability of neutron reflection (NR) to study the structural changes of multi-component lipid monolayer models mimicking...

Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Previously we studied discs formed using...

Hydrophobins are small compact secreted fungal proteins which are strongly surface active and adhere to both hydrophobic and hydrophilic surfaces. Their strong surface activity...