53 datasets found

The main objective of the present study is to gain an understanding of the nature of the interaction of ¿phospholipid membranes¿ with small, interfering RNA (siRNA) in the...

Complexes prepared from cationic, dichain lipid (L) vesicles and negatively charged siRNA (R), with and without positively chargely targeting peptides (P) known as LR or LPR...

Cubosomes and hexosomes are particles with internal liquid crystal structures of the bicontinuous cubic or reverse hexagonal nanostructures respectively. The nanostructure...

The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents. The successful development of...

Here we propose to look at the structure of two phosphocholine lipids, and their larger scale structures in aqueous solution. Depending on the length of the fatty acid chain in...

Ce3Co4Sn13 is a cubic heavy Fermion system which resides close to a magnetic instability.Under ambient conditions Ce3Co4Sn13 exhibits an extremely large (4 J/mol Ce K2) peak in...

CePd3 is a classic intermediate valence (IV) system. In MAPS experiment 620167 we obtained an important qualitative result for CePd3, namely that the Kondo-like scattering...

We propose to use the OSIRIS spectrometer to measure the inelastic magnetic scattering on the newly discovered heavy Fermion compound Ce3Co4Sn13. This compound has one of the...

Gene delivery vehicles, known as LPD complexes, prepared from mixing cationic lipid vesicles (L) with cationic peptide (P) and DNA (D) have proven to be very effective at...

In this proposal we intend to investigate the intermolecular interactions in a mixed phospholipid/cholesterol monolayer at the oil-water interface using neutron reflectometry....

It is well known that water is the medium in which the overwhelming majority of biological processes take place. In cell membranes water molecules are thought to be essential to...

The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the...

The main objective of the present work is to complete some work aimed at gaining an understanding of the interaction of phospholipid membranes containing the neutral helper...

Building on the success of our earlier work, we now propose to use SANS to examine the floc structure and sedimentation behaviour of silver nanoparticles in wastewater matrices...

Membrane receptor proteins (MRPs) which are thought to represent the majority of drug targets are challenging to study as their structure and function is dependent on being...

We propose to look at the interaction of the aggregates two phospholipids form with two phospholipase (PL) enzymes, PLA2 and PLC, which hydrolyse different ester groups in the...

A family of sterol-modified glycerophospholipids (SML) have been synthesized in which the sn-1 or sn-2 position is covalently attached to cholesterol and the alternative...

The aim of the current project is to probe (at the nanometer length scale) the relationship between the solution structures of a surfactant molecule, the aggregate(s) it forms...

Despite interest in microemulsions as drug delivery vehicles, there is a lack of structural understanding to justify the formulations used. The present study examines the use of...

The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the...