273 datasets found

The aim of this experiment is to explore a very recent discovery made by ourselves that shear flow can suppress the nucleation and growth of crystals of specific low molar mass...

This proposal focuses on a new approach to the formation of rod-like micelles in supercritical CO2 (scCO2). Recent successful high-pressure SANS (HP-SANS) results have shown for...

This proposal involves manipulating the curvature of aggregated polar materials in supercritical CO2 (scCO2) by tuning the mixing ratio of fluorocarbon (FC) and hydrocarbon (HC)...

Surprisingly little work has been done to gain understanding about the nature, stability and properties of nanoparticles dispersed in organic solvents (organosols). Recently...

Despite interest in microemulsions as drug delivery vehicles, there is a lack of structural understanding to justify the formulations used. The present study examines the use of...

We plan to carry out SANS experiments on a bacterial colonization factor to elucidate how it interacts with chitin, which is found on the surface of plankton and crustaceans....

We have recently developed a method to prepare a wide variety of amphiphilic diblock copolymers through a supramolecular linkage that is stable in water. This has been achieved...

Hydrophobins are secreted fungal proteins and are small lipopeptide biosurfactants. They are strongly surface active and self-assemble at interface, and these unique film...

We will measure the solution structure of a protein complex from bacteria essential for cell division. The two proteins, FtsA and FtsZ, are known to interact with each other...

The understanding the drug release mechanism from polymeric nanoparticles (PNPs) requires a detailed characterisation of the PNPs internal structure. Small-angle neutron...

The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the...

The separation of particular lipids in cell membranes into liquid ordered and liquid disorder regions is thought to have a major influence of the functioning of membrane...

Large multiprotein complexes are the new frontier in structural biology. Individual proteins may be solved by X-ray crystallography but the relationships between subunits and...

In this part of proposed work, we wish to explore how antibiotics minocycline and tetracycline interact with model lipid bilayers in the form of SUVs, mimicking key features of...

This proposal is part of a new project based on understanding the formation of gels in suspensions of partially oxidised cellulose nanofibrils with small amounts of salt or...

It is proposed to use small-angle neutron scattering (SANS) to investigate in detail the binary phase diagram between 1-ethyl-3-methylimidazolium...

Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Previously we studied discs formed using...

Hyaluronic acid (HA) plays a key role in tumour cell bio-adhesion and, as such, this interaction opens up possibilities for targeted tumour pathologies We have created a...

This proposal explores headgroup-free, fluorocarbon-hydrocarbon hybrid compounds able toform viscous elongated aggregates in supercritical CO2 with the aim of improving...

Coacervates have been studied for a long time for their unusual properties: they are dense networks of charged polymers that are soluble in water. Instead of flocculating when...