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Molecular architecture of novel, trichain-containing vectors for gene delivery
We have recently developed novel ternary lipopolyplex vectors (i.e. gene delivery vectors containing cationic lipid, plasmid DNA and a cationic peptide) in which, for the first... -
Nanostructure definition in electrospun fibres of polymer blends
This proposal is part of a research programme which is focused on nano-fibres prepared by electrospinning. The programme is centered on the spinning... -
Self-assembly of GFP-HMPA protein polymer conjugates: Effect of polymer hydro...
Conjugation of therapeutic proteins to polymers is well established but most methods result in multi-site and multiple conjugation, crosslinking resulting in lack of orientation... -
Solubilisation of Drug Molecules in Nonionic Surfactant Micelles: Structural ...
This proposal aims to understand how the structure of non-ionic surfactant micelles affects the amount of fungicides solubilised. SANS is a technique unique for unravelling the... -
Structure of Cellulose Nanofibril Gels with Alcohols
Our group has been working partially oxidized cellulose nanofibrils which form gels in aqueous formulations. Recently we have observed that these fibrils also gel when dialysed... -
Quantifying the adsorption of lecithin on sucrose particles to understand cho...
Small angle neutron scattering will be used to directly quantify the adsorption of lecithin at the interface between partially deuterated sucrose particles contrast-matched to a... -
The effect of unsaturation on the shear dependence of cationic lamellar phase...
Products such as fabric and hair conditioners are commonly in the form of di-alkyl chain cationic lamellar phase dispersion. The effects of shear on such lamellar phase... -
Polystrene chain conformations in good solvents and electrospun fibres
This proposal is centered on the preparation of nanoscale fibres prepared by electrospinning and is the focus of the final year PhD programme of Saeed Mohan. These experiments... -
New surfactants forming anisotropic micelles and microemulsions in CO2
An analogue of the popular surfactant AOT with isopropyl glycol tails (IG-AOT, Figure.1) has been recently designed as a co-surfactant for water-in-CO2 (w/c) systems: stable... -
Small-angle neutron scattering studies of phase separation in Fe-Cr based alloys
Iron-Chromium is an ideal model system to improve the fundamental understanding of phase separation with vital engineering applications. For instance, ferritic and duplex... -
Search for magnetic domains in frustrated magnet CaFe2O4
We propose to study the temperature dependence of the size and shape of the magnetic domains believed to exist in CaFe2O4 - a frustrated triangular antiferromagnet. Our diffuse... -
SANS Xpress XB1690206
This dataset has no description
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Effect of reversing lipid head group charge on vesicular properties
Zwitterionic lipids such as phosphatidylcholine (PC) are major components of the membranes that compartmentalize organisms. Although there is a large literature on PC, cationic... -
Effect of surfactant head group on micelle structure of drug containing micelles
The aim of the current project is to probe (at the nanometer length scale) the relationship between the solution structures of a surfactant molecule, the aggregate(s) it forms... -
Understanding drug carrier interactions in the stomach
In a pharmaceutical industry context, hydrophilic polymeric matrices are a popular methodology for extending the release of drugs. However, issues sometimes arise -... -
Gold-loaded microgels
Recent results show that gold nanoparticles (Au-NPs) can be included into microgels (MGs). UV-visible spectra (Figure 1) suggest the original Au-NP sols retain their size and... -
NTC Practical
This dataset has no description
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Competitive and synergistic interactions in gel formation
The interactions of small molecules with Pluronic copolymers are of relevance to their numerous pharmaceutical, domestic, technological and industrial applications. Whereas the... -
Organogels for applications in CO2
This proposal aims to explore organogel systems, like those recently decsribed1-3, but made from new CO2 philic surfactant-gelators. These have been synthesised to feature... -
TK49_TRANS
This dataset has no description
