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Structure of lipid monolayers following oxidative damage
Lipids form the major component of cell membranes, which separate the contents of the cell from the external environment. The oxidation of lipids within biological membranes is... -
Influence of Alkyl Chain Fluidity on the Membrane Binding Activity of Cationi...
Skin becomes a target of drug delivery because the transdermal routes are non-invasive, can be self-administrated, improves patient compliance and can provide a release for long... -
Lipid bilayers suspended beneath the air/water interface for neutron reflecti...
Bacterial membranes contain safety valves called mechanosensitive ion channels, which protect the bacterium from changes in the osmotic pressure of their environment. However,... -
Elucidating the effect of BTHC on DMPC monolayers
Plastic bags are used as containers for storage of donated blood. These bags are often made of PVC plasticized with dialkylphthalates (e.g. DEHP), which migrates into the blood... -
Effect of squalene on membrane structure and Amphotericin B resistance in Can...
The yeast Candida glabrata is becoming an increasing cause of infections. We have developed RNA interference tools that allow us to study the virulence and resistance mechanisms... -
Joint Diamond/ISIS proposal 22078
The basis of a biological cell membrane is a lipid bilayer containing functional proteins. Its purpose is to form a selective barrier that separates the aqueous fluids inside... -
The Effect of the Head Group on Multilayering of Alkanoic Alkyl Ester Sulphon...
We have shown that under certain conditions multilayer adsorption of surfactants occurs at the air-water interface. in which case the system becomes a powerful wetting agent (it... -
Binding studies of Quantum Dots and Pore-Forming Proteins on multi-component ...
Cell membrane being the first line of defence of a complex cell, it forms an important scientific topic to study its encounter with various external entities. Nanoparticles are... -
Interfacial structures and competitive adsorption of amphiphilic millipede po...
Foam stability, appearance and functionality is governed by the thin liquid films between foam bubbles. These films are stabilised by surface active molecules (surfactants and... -
Ibuprofen containing surfactant monolayers: location and stiochiometry of ibu...
An increasing number of potential drug molecules are extremely water insoluble, limiting their commercialisation as medicines. Solubilisation of drug in surfactant micelles is a... -
Determination of the absorbed amount and location of a hydrophobic drug in su...
Many drugs are both poorly water-soluble (hydrophobic) and lipophilic in nature and are therefore incorporated into surfactant micelles and monolayers. As the incorporation of... -
Mixed H/F-Carbon surfactant monolayers for fire-fighting applications
The aim is to use Neutron Reflectivity (NR) to gain essential information on the adsorption properties of fluorocarbon/ hydrocarbon mixtures in commercial fire-fighting foam... -
The structure of glycerol mono oleate at the iron oxide/dodecane interface
The reliability of combustion engines is enhanced by lubrication, which provides wear protection along with reduced emissions and fuel consumption through the minimisation of... -
Lipid bilayers suspended beneath the air/water interface for neutron reflecti...
Bacterial membranes contain safety valves called mechanosensitive ion channels, which protect the bacterium from changes in the osmotic pressure of their environment. However,... -
More than the sum - oxidation behaviour of mixed fatty acid monolayers
Single molecule thin films of various surface-active species are found on the surface of water bodies from the sea down to microscopic spray droplets. These films affect the... -
Interactions of de Novo Designed Antimicrobial Lipopeptides with Model Leafle...
In this work, we propose to exploit the unique capability of neutron reflection (NR) to study the structural changes of multi-component lipid monolayer models mimicking... -
Interaction of Surfactant with Model Lipid Membranes: Influence of Surfactant...
Skin becomes a target of drug delivery because the transdermal routes are non-invasive, can be self-administrated, improve patient compliance and can provide release for long... -
Neutron reflectivity studies of the interaction between a novel antimicrobial...
A Unilever proprietary technology has been shown to inhibit biofilm growth and development, and is also found to possess antimicrobial activity, effective both as a... -
Antimicrobial Mechanisms of Model Biocides via Their Interaction with Lipopol...
The global increase of bacterial resistance to antibiotics has led to increasing interest in research focusing on the development and characterization of new antimicrobial... -
Structures of cardiolipin-bound cytochrome c in pathological conditions
Cardiolipin (CL) is a structurally unique dimeric phospholipid localized in the inner mitochondrial membrane, which is known to provide essential structural and functional...