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Function and Structure of Reconstituted Neurotransmitters in biomembranes
Neurotransmitter transporters recognize biogenic amines dopamine, serotonin, noradrenalin and γ-amino butyric acid (GABA). They all belong to the family of... -
Structure of Confined Mucin Films
Nowadays, a significant research effort is devoted to understand and mimic biological lubricants which, in contrast to most man-made lubricants, are based on water. It has been... -
Interaction of Low Density Lipoproteins (LDL) with Model Mammalian Cell Membr...
Atherosclerosis and subsequent clinical complication is one of the biggest killers in the western world, with a death toll reaching 16.7 million deaths per year. Although many... -
Lipid exchange between high density lipoprotein (HDL) and model phosphatidylc...
Lipoproteins are the main carriers of lipids in the body. HDL is believed to favor cholesterol removal and decrease the risk to develop atherosclerosis and related... -
Using the nano discs approach at surfaces to determine the relation between s...
Membrane bound proteins continue to be to date the most elusive molecules in nature, since they are only functional in the lipid bilayer. We have developed a method to study... -
Reconstituted lipoprotein particles - Implications of structure and dynamics ...
Neutron scattering will allow to advance the understanding of lipoprotein behavior in solution and at the interface of relevant biological interfaces. Here we focus on HDL... -
Novel Coatings For Specific Binding Of Membrane Proteins On Surfaces
We have developed a novel approach for biomimetic coatings for protein tethering on surfaces with minimal unspecific protein adsorption. This coating has been fully optimised... -
Interactions between lipoprotein particles from human serum and model blood v...
In westernised societies, atherosclerosis and its clinical consequences such as heart disease and stroke constitute the leading cause of death. Thus, the prevention or... -
Self-assembling antimicrobial peptides: interactions with model lipid membranes
We propose to investigate antimicrobial peptides that self-assemble into well-defined nanostructures. Previous SAXS results have shown that the peptides form rather robust... -
NR characterization of aquaporin-containing silica-reinforced supported PC bi...
Despite the abundancy of sea water there are 663 million people that lack access to safe drinking water. This is due to excessive energy consumption and hence cost coupled to... -
Structure of Confined Mucin Films
Nowadays, a significant research effort is devoted to understand and mimic biological lubricants which, in contrast to most man-made lubricants, are based on water. It has been... -
The Interactions of Blood Components with Models of the Gram Negative Bacteri...
One of the major challenges in the fight against antimicrobial resistance is the development of antimicrobial compounds that selectively disrupt bacterial membranes and leave... -
Effect of membrane fluidity for novel dendrimer drug interaction and uptake m...
Bacteria growing resistant to common antibiotics is a growing problem and research in new types of medicines which do not induce resistance is therefore very important. Novel... -
Lipid exchange dynamics between native lipoprotein particles and human cell m...
Atherosclerosis is the primary cause of death in westernized societies. Clinical indicators include not only the net lipoprotein concentration but also the ratio between the... -
Membrane Composition-Dependent Interaction between Beta-Arrestins and Lipid M...
Beta-arrestins are proteins that regulate GPCR signaling, e.g. by recruiting endocytic components to remove the receptor from the plasma membrane. Our fluorescence microscopy... -
Neutron scattering and selective deuteration for elucidating how lipids regul...
Plants biosynthesise valuable pharmaceutical compounds by a series of enzyme complexes (or metabolons) that work in a concerted action. Metabolons enhance substrate channeling... -
Role of apolipoprotein E variant on HDL interactions at model cell membranes
Atherosclerosis is the leading cause of death in western society, its consequences such as strokes and heart attacks arise from the build-up of plaques of fat which accumulate... -
Cell-penetrating peptides interaction with model membranes
Cell-penetrating peptides (CPPs) are short cationic peptides that are efficiently taken up by cells. They are able to co-internalize therapeutic molecules into cells for... -
A new approach to look at membrane in plane organisation via giSANS
Biological membrane in plane organisation is a challenging topic, specially since it has been suggested to depend on curvature. So far the main approach to study curvature... -
Sequential adsorption of atherosclerotic lipoproteins to study the protective...
Atherosclerosis is a major contributor to global morbidity and mortality with 31 % of all deaths in 2008 linked to cardiovascular disease. The development of the disease has...
