Neutron scattering will allow to advance the understanding of lipoprotein behavior in solution and at the interface of relevant biological interfaces. Here we focus on HDL fractions extracted from blood and reconstituted with given apolipoproteins. Their structure and ability to exchange lipids is likely to be dependent on the apolipoprotein isoform. Here we will focus on both the structure and lipid exchange dynamics of these particles using as a reference model cellular membranes made of invisible phosphatidylcholine.