114 datasets found

The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the...

The main objective of the present work is to complete some work aimed at gaining an understanding of the interaction of phospholipid membranes containing the neutral helper...

Small angle neutron scattering (SANS) studies in combination with contrast variation will be used to determine the molecular architecture of...

Building on the success of our earlier work, we now propose to use SANS to examine the floc structure and sedimentation behaviour of silver nanoparticles in wastewater matrices...

Membrane receptor proteins (MRPs) which are thought to represent the majority of drug targets are challenging to study as their structure and function is dependent on being...

Solubilisation of poorly-water soluble drug in surfactant micelles is an attractive means of increasing the apparent aqueous solubility of such drugs in order to administer the...

The very heterogeneous, but non-random, arrangement of lipids and proteins in cell membranes are of major scientific interest and led Simons and Ikonen to propose that ¿rafts,¿...

We propose to look at the interaction of the aggregates two phospholipids form with two phospholipase (PL) enzymes, PLA2 and PLC, which hydrolyse different ester groups in the...

A family of sterol-modified glycerophospholipids (SML) have been synthesized in which the sn-1 or sn-2 position is covalently attached to cholesterol and the alternative...

At King¿s College London we have recently developed a novel combination formulation (a nanosuspsomicroemulsion) comprising of a microemulsion containing one drug and polymer...

Lipid oxidation is linked to many adverse health effects. In this proposal we will use QENS in combination with contrast variation as a non-invasive method to detect and...

The very heterogeneous, but non-random, arrangement of lipids and proteins in cell membranes, known as rafts are of major scientific interest. Lipids in cell membranes are...

There is an urgent need for development of novel antimicrobial therapies, and the mammalian theta-defensins and protegrins seem to offer significant potential in this regard....

The aim of the current project is to probe (at the nanometer length scale) the relationship between the solution structures of a surfactant molecule, the aggregate(s) it forms...

A Unilever proprietary technology has been shown to inhibit biofilm growth and development, and is also found to possess antimicrobial activity, effective both as a...

Despite interest in microemulsions as drug delivery vehicles, there is a lack of structural understanding to justify the formulations used. The present study examines the use of...

The understanding the drug release mechanism from polymeric nanoparticles (PNPs) requires a detailed characterisation of the PNPs internal structure. Small-angle neutron...

The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the...

The separation of particular lipids in cell membranes into liquid ordered and liquid disorder regions is thought to have a major influence of the functioning of membrane...

An number of potential drugs are extremely water insoluble, limiting their commercialisation as medicines. Solubilisation of drug in surfactant micelles is a means of increasing...