This study investigated the interactive effects of ocean warming and acidification on the feeding behavior and physiology of two sympatric amphipods, Hyale niger and Cymadusa filosa. Using an orthogonal experimental design with two temperatures (27 °C and 30 °C) and two pH levels (7.8 and 7.5), we assessed feeding rates, respiration rates, ammonAnimaliaia excretion, and O/N ratios. This dataset is included in the OA-ICC data compilation maintained in the framework of the IAEA Ocean Acidification International Coordination Centre (see https://oa-icc.ipsl.fr). Original data were downloaded from Mendeley Data (see Source) by the OA-ICC data curator. In order to allow full comparability with other ocean acidification data sets, the R package seacarb (Gattuso et al, 2024) was used to compute a complete and consistent set of carbonate system variables, as described by Nisumaa et al. (2010). In this dataset the original values were archived in addition with the recalculated parameters (see related PI). The date of carbonate chemistry calculation by seacarb is 2025-06-25.