The hydration and ordering of lamellar block copolymer films prior to the formation of polymer vesicles

DOI

The key to the use of polymer vesicles as effective molecular delivery systems is in the ability to efficiently encapsulate a molecular payload within the vesicle. We would like to use neutron reflectivity to probe the non-equilibrium mechanisms that underlie vesicle formation for a series of model vesicle forming block copolymers. The experiment will involve studying the hydration and ordering of lamellar block copolymer films prior to the formation of polymer vesicles. As we would like to understand the processes by which the block copolymer film orders prior to vesicle formation. The instrument INTER will enable us to follow the kinetics of the phase changes and swelling of the lamellar layers and hopefully enable strategies that will improve encapsulation efficiencies making these materials more viable for use as drug delivery agents.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24079476
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24079476
Provenance
Creator Professor Richard Jones; Dr Andrew Parnell
Publisher ISIS Neutron and Muon Source
Publication Year 2014
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2011-05-21T08:02:14Z
Temporal Coverage End 2011-05-23T07:37:17Z