Effect of monodispersity on core crystallinity, core packing and nanoparticle morphology of self-assembled block-co-polymers

DOI

The still unreached goal of nanomedicine is to deliver drugs which are only released in the diseased tissue in a controlled fashion. For this, tailorable, reproducible, and highly controlled drug delivery systems are required. Whereas nature uses discrete building blocks, the current status quo in drug delivery is the use of ill-defined polydisperse macromolecules. Synthetic efforts in material science yielded discrete macromolecules which have astonishingly different properties than their polydisperse counterparts. Here the self-assembly of discrete block-co-oligomers in water is compared to their polydisperse counterparts. Gaining structural insight into these systems will help in establishing the effect of monodispersity on size, architecture, core-crystallinity and packing, all important parameters to control stability and the uniformity of drug release.

Identifier
DOI https://doi.org/10.5286/ISIS.E.97999642
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/97999642
Provenance
Creator Dr Katja Petkau-Milroy; Dr Robert Dalgliesh; Dr Ilja Voets; Miss Marle Vleugels; Dr Rodrigo Magana Rodriguez
Publisher ISIS Neutron and Muon Source
Publication Year 2021
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Chemistry; Life Sciences; Medicine; Natural Sciences
Temporal Coverage Begin 2018-09-11T23:00:00Z
Temporal Coverage End 2018-09-15T23:00:00Z