The aim of this project is to systematically study the direct and moderating impacts of cultural background, individual characteristics such as personality, motivation, or self-regulatory skills, and other resources such as social support on individuals’ professional trajectories and their career development. In order to do so, a longitudinal approach is implemented, implying a 7-year follow up of a large sample of workers and unemployed individuals, Swiss and non-Swiss. Since almost no longitudinal studies of professional trajectories based on a psychological perspective are available, we claim that this project bringing together different disciplinary specializations (personality and crosscultural psychology, career development psychology, positive psychology, work and organizational psychology) and combining different methodological approaches can extend and integrate the results obtained in specific research domains.