Variability is one of the extreme observational properties of BL Lacertae objects. AO 0235+164 is a well-studied BL Lac throughout all electromagnetic wavebands. In the present work, we show its optical R-band photometric observations carried out during the period from 2006 November to 2012 December using the Ap6E CCD camera attached to the primary focus of the 70cm meniscus telescope at Abastumani Observatory, Georgia. During our monitoring period, it showed a large variation of {Delta}R=4.88mag (14.19-19.07mag) and a short timescale of {Delta}T_v_=73.5minutes. During the period of 2006 December to 2009 November, we made radio observations of the source using the 25m radio telescope at Xinjiang Astronomical Observatory. By adopting a discrete correlation function to the optical and radio observations we found that the optical variation leads a radio variation of 23.2+/-12.9days.