Investigation of the effect of adjuvants on the sphere-to-rod transition in swollen polymeric micelles

DOI

Small aromatic compounds are strongly solubilised by Pluronic block copolymers. This includes adjuvants, which are compounds used in the pharmaceutical industry to aid drug delivery. It is therefore important to gain a better understanding of the changes that occur upon the addition of adjuvants to micellar solutions of Pluronic block copolymers, which are of interest as potential drug delivery vehicles, as well as the changes that take place as the solutions are heated from room temperature to body temperature. Previous SANS investigations show significant changes occur as the samples are heated when benzyl alcohol is used as the adjuvant. It is however not clear whether the observed effect is the result of a change in the intermicellar interaction potential or a sphere-to-rod transition. We wish to use shear-SANS to determine this in an unambiguous fashion.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24077348
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24077348
Provenance
Creator Professor Terence Cosgrove
Publisher ISIS Neutron and Muon Source
Publication Year 2012
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2009-09-25T08:01:19Z
Temporal Coverage End 2009-09-26T16:27:17Z