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Structure of lipid monolayers following oxidative damage
Lipids form the major component of cell membranes, which separate the contents of the cell from the external environment. The oxidation of lipids within biological membranes is... -
In-situ reaction of lithium amide or imide with manganese(IV) oxide
We request 3 days beam time on POLARIS for in-situ powder diffraction studies of the reactions of lithium amide or lithium imide with manganese(IV) oxide under flowing argon or... -
Antibiotic binding to a bacterial outer membrane model containing oriented pr...
The Outer Membranes (OM) is a feature of many pathogenic bacteria. It is important as a barrier to antibiotics & the site of human-bacteria interaction. However bacteria are... -
Formation and ammonia decomposition behaviour of lithium nitride hydride
Ammonia is seen as a key part of the transition to a sustainable energy economy, but needs decomposition catalysts to release its stored hydrogen. Lithium nitride-hydride... -
Investigating the structure of the pulmonary lung surfactant at the air-water...
The lung surfactant is a film coating the alveolus of the lung. We want to characterize the structure of this film at the air-water interface at a molecular level. This will... -
In-Situ Studies of Alternative Mobile-Ions for High-Temperature Thermal Batte...
Whilst rechargeable batteries continue to take over the consumer electronics market, they are unsuitable to replace specific battery technologies, such as the thermal battery,... -
Solid-supported lipid bilayers for studying mechanosensitive ion channels: to...
Bacterial membranes contain safety valves called mechanosensitive ion channels, which protect the bacterium from changes in the osmotic pressure of their environment. However,... -
Investigation of diffusion of branched alkanes in ZSM5
The diffusion coefficients of monobranched and dibranched (methyl)hexane and octane in industrially important zeolite ZSM5 will be measured along with their straight chain... -
Dynamical Characterisation Of Conjugated Polymer Nanocomposites Used for Plas...
Research on organic photo-voltaics (PVs) has increased dramatically in the last few years, owing to the promise of low manufacturing costs, high production throughput and large... -
Introducing the O-antigen in Bacterial Outer Membrane in vitro Models Pt. III...
The Gram negative bacterial outer membrane protects the bacterium from external toxins such as antibiotics. This is partially responsible for Gram negative bacteria becoming the... -
Role of apolipoprotein E variant on HDL interactions at model cell membranes
Atherosclerosis is the leading cause of death in western society, its consequences such as strokes and heart attacks arise from the build-up of plaques of fat which accumulate... -
Comparing the assembly of LPS into model Outer Membranes by Langmuir-Blodgett...
We have recently created and published a model of the Gram negative bacterial Outer membrane (OM) which recreates many aspects of its behaviour and will improve our ability to... -
Towards the development of carbonitrides as novel two-stage regenerable reage...
We are examining a number of cobalt-molybdenum carbonitrides as possible catalysts for reactions that produce nitrogen-containing organic molecules. There is good evidence that... -
Hydrogen from ammonia using lithium imide metal nitride composites
Light metal amides and imides are a new class of highly active ammonia decomposition catalysts. Indeed, composites of lithium imide and transition metal nitrides are likely to... -
Satisfying the need for contrast in antimicrobial research
Gram-negative bacteria, which cause a variety of diseases including meningitis, plague, sepsis and food poisoning, are becoming increasingly antibiotic resistant. One reason is... -
Multiscale studies of crystallisation in synthetic polymers
We will exploit the unique capability of NIMROD to bring new understanding to the way in which long chain polymers crystallise. There are three key length scales: the first... -
Interaction of thermo-responsive deutrated nanogels with lipid monolayer at t...
Drug delivery through skin is an important delivery route. However, the outermost layer of the skin provides a formidable barrier to dermal absorption and penetration for... -
Antibiotic paths through the bacterial outer membrane: The strange case of va...
Gram-negative bacteria, which cause a variety of diseases including meningitis, plague, sepsis and food poisoning, are becoming increasingly antibiotic resistant. One reason is... -
Direct Observation of Gram Negative Bacterial Membrane Disruption by Supramol...
Cyclic peptides with alternating side chain stereochemistry are capable of self-assembling into long nanotubes. The conjugation of polymers to these peptides renders the... -
Investigation of the effect of adjuvants on the sphere-to-rod transition in s...
Small aromatic compounds are strongly solubilised by Pluronic block copolymers. This includes adjuvants, which are compounds used in the pharmaceutical industry to aid drug...