Metatranscriptome: Modulation of small intestinal microbial activity induced by 2 weeks consumption with 2 fermented milk products; a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients

DOI

Ileostomy effluent samples were collected for metatranscriptomic profiling. The samples were collected for the INSIDE explorative diatry study. The study was aimed to characterize the impact of fermented food may have on the small intestinal microbiota and systematically.

Date Submitted: 2021-11-23

Ileostomy-cohort-study-with-two-probiotics, a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients; INSIDE project: Ileostomy-cohort-study-with-two-probiotics, a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients Information: The aim of the study is to determine the small intestinal microbiota response in humans to probiotic supplement interventions for two consecutive weeks, and to relate this to intestinal barrier function and immune and metabolic responses in blood, as functional outcome parameters of host physiology. A small cohort of ileostoma subjects has been recruited to participate in a three-arm intervention trial according to a double blind, cross-over, placebo-controlled design. Two probiotics products and a placebo were administered in random order to each volunteer for two weeks with 2 week wash-out periods in between interventions. The volunteers will participate in this study for approx. 100 days and will, in addition to the three interventions, not consume fermented products.

Identifier
DOI https://doi.org/10.17026/dans-xvh-yww8
Metadata Access https://lifesciences.datastations.nl/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=doi:10.17026/dans-xvh-yww8
Provenance
Creator E. Zaccaria; T. Klaassen; A.M.E. Alleleyn; J. Boekhorst; T. Smokvina; M. Kleerebezem; F.J. Troost
Publisher DANS Data Station Life Sciences
Contributor Data Librarian; Wageningen University & Research
Publication Year 2022
Rights CC-BY-4.0; info:eu-repo/semantics/openAccess; http://creativecommons.org/licenses/by/4.0
OpenAccess true
Contact Data Librarian (Wageningen UR)
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Version 1.1
Discipline Life Sciences; Medicine