This dataset contains measured dissolved trace element concentrations (Fe, Mn, Co, Ni, Cu, Zn, Cd and Pb) of station depth profiles sampled in Fram Strait (North Greenland Sea) during GEOTRACES expedition GN05 (PS100) between 21 July and 1 September 2016. Samples were collected strictly following GEOTRACES guidelines (Cutter et al., 2017; https://www.geotraces.org) and analysed exactly as per Rapp et al., 2017 ( Anal. Chim. Acta; doi:10.1016/j.aca.2017.05.008). Concentrations were intercalibrated with GEOTRACES reference materials SAFe S and GSC (Bruland Research Lab), with exception of dissolved Cd data. Information on the analytical procedure including reference materials and limits of detection can be found in related published manuscripts, the PhD thesis of Stephan Krisch (Christian-Albrechts-Universität zu Kiel) or can be obtained from the authors upon request. Table caption: Measured concentrations of dissolved trace elements in Fram Strait sampled during GEOTRACES expedition GN05 (PS100) between 21 July-1 September 2006. Uncertainty is calculated as one standard deviation (1σ, STD) to replicate measurements via ICP-MS. ND = no data. Use of quality flags (QF) according to GEOTRACES policy (https://www.geotraces.org/geotraces-quality-flag-policy/). Plesae note, dissolved Cd data is not quality controlled. Somes samples were pooled (indicated in column "Bottle") from different bottles at one depth; the concentrations reflects the mean and the corresponding uncertainty is calculated as the standard deviation to replicate measurements. Trace metal concentrations at station 24 may show larger variations between different bottles at one specific depth. Because station 24 is located at Dijmphna Sund entrance sill, we associate these discrepancies to the water column's strong lateral and vertical turbulence (see ucCTD physical oceanography data) (e.g. Mortensen et al. 2011, 2013, Carroll et al. 2017) that goes in hand with localized TM aggregation-dissolution and sediment resuspension processes, thus affecting TM fractionation (e.g. Homoky et al. 2012).