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Structure determination of solution aggregation of single alkyl chain PC surf...
We have synthesised alkyl phosphorylcholine (CnPC) surfactants in hydrogenated and deuterated form and have determined their solution aggregation using SANS. In this part of... -
Part B: Binding behaviour of PAMAMs G5 and G4.5 to zwitterionic and anionic l...
Polymers are commonly used in drug delivery to create dosage forms that enable delivery of the active ingredient to the site of action within the body. Towards controlled drug... -
Kinetics of surfactant multilayer formation / dissolution at interfaces
The formation of multilayer structures at surfaces and interfaces from self-assembly in mixed surfactant and in polymer / surfactant mixtures has been recently reported, and... -
Molecular Mechanistic Processes of Complexation between DNA and Cationic Copo...
We have previously used LOQ to identify the complex (polyplex) structures formed between a short single strand DNA and a cationic diblock copolymer MPC30-DEA60. The SANS... -
Interfacial layer structure of designed linear lipopeptides
Lipopeptide surfactants are a group of interesting biosurfactants due to their natural origin and their high effectiveness at reducing interfacial tension. However, there is a... -
Solubilisation of Drug Molecules in Nonionic Surfactant Micelles: Structural ...
This proposal aims to understand how the structure of non-ionic surfactant micelles affects the amount of fungicides solubilised. SANS is a technique unique for unravelling the... -
Solution aggregation of short peptide amphiphiles
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly to lead to interfacial adsorption and solution nano-aggregation.... -
Kinetic Study of the Mechanistic Complexation Process Between DNA and Cationi...
We propose to use the new SANS2d to study the dynamic structural evolution in the couse of the formation of DNA-cationic polymer complexes. The dynamic process and the mixing... -
The use of lipid sponge-like nanoparticles as carriers for macromolecules and...
Biological membranes do not only occur as planar bilayer structures, but bilayers have also been shown to, depending onthe lipid composition, curve into intriguing 3D... -
Surface properties of biogenic polyamine-surfactant mixtures
Polyions and biogenic polyamine are ubiquitous in many important biochemical functions. We propose here to use neutron reflectivity to investigate their potential to induce and... -
Surface properties of biogenic polyaminesurfactant mixtures
Polyions and biogenic polyamine are ubiquitous in many important biochemical functions. We propose here to use neutron reflectivity to investigate their potential to induce and... -
SANS study of the structure of surfactant stabilised Pt and Ru nanoparticles
Surfactants have been used to bind and disperse Pt and Ru nanoparticles during their synthesis. In this work, we propose to use SANS to determine the thickness and packing... -
Interfacial adsorption of monoclonal antibody and antigen binding
Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element... -
Interactions between Designed Antimicrobial Lipopeptides and Inner Membrane L...
Neutron reflection will be used to reveal the structural changes from different inner membrane leaflet models upon interacting with a group of antimicrobial lipopeptides with... -
Insertion of antimicrobial peptides into phospholipid monolayers at air/liqui...
We have designed a series of cationic peptides with different helix repeats that can kill bacteria but remain benign to mammalian host cells. The selectivity to cell types is... -
Interfacial adsorption of single alkyl chain PC surfactants (CnPmC)
We propose to investigate the interfacial adsorption of a series of water-soluble single chain PC surfactants using neutron reflection, focusing on assessing the effects of... -
Adsorption of modified PEI / SDS mixtures at the solid-solution interface
Polymer-surfactant mixtures are extensively used in a wide range of domestic, industrial and technological applications. This proposal is part of a collaboration between Oxford... -
Interfacial layer structure of designed lipopeptides at the solid/water inter...
Lipopeptide surfactants are a group of interesting biosurfactants due to their natural origin and their high effectiveness at reducing interfacial tension. However, there is a... -
Adsorption of Monoclonal Antibodies at the Solid/liquid Interface
We propose to use neutron reflection to study the interfacial adsorption of 2 novel bispecific therapeutic antibodies at the silicon oxide/water interface. To enpower each of... -
Effect of terminal blocking groups on solution aggregation of short peptide f...
Short peptide sequences such as KLVFFAE form well defined beta sheet structures. Their further templating through hydrophobic interactions and hydrogen bonding is the principal...