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Single proton short time dynamics in Pd/Ag membranes
Pd-Ag membranes used in Fusion machines for isotopic separation of H isotopesa can also be used for the production of ultrapure H with interesting applications in renewables.... -
The effect of dendrimer surface functionalization on the interaction with mod...
Dendrimers are a unique class of nano-structured vehicles for drug and gene delivery into intracellular targets. Their surface chemistry influences their transport across... -
Micelle curvature effects on polyelectrolyte-surfactant film structures
This proposal continues our investigations into polyelectrolyte-surfactant thin films which form at the air-solution interface. Our previous work investigated structure... -
Investigations of atomic and intermediate-range structure in model membranes
This proposals aims to investigate the atomic and intermediate range structure in model membrane environments. By beginning with a disperse system of a phosphocholine lipid in... -
Understanding anaesthetics: Ethanol partitioning into lipid membranes, effect...
Ethanol plays an important role in the human metabolism. It is in particular known to act as a drug enhancer by increasing trans-membrane permeability, and as an anesthetic.... -
Amyloid β peptide and α-synuclein association at lipidmodel membranes
We plan to investigate the interaction between amyloid proteins and model biomembranes deposited on solid surfaces. The model membranes will be single zwitterionic and mixed... -
Microdomains in model membranes using contrast variation SANS
In the present proposal small angle neutron scattering will be used in combination with contrast variation as a non-invasive method to detect the presence and size formation of... -
Interaction between the bioactive lipopeptide fengycin and lipid membranes
One class of bioactive lipopeptides produced by Bacillus subtilis, fengycin, has strong surfaceactivity and interesting antifungal property with low hemolytic activityTo gain... -
Conformational analysis of subtilin / lipid II binary antibiotic/target membr...
Antibiotic resistance is pathogenic bacteria is a major clinical problem. Resistance to all antibiotiotic classes, currentl yin clinical use, has been reported. By contrast, the... -
Understanding anaesthetics: Ethanol partitioning into lipid membranes, effect...
Ethanol plays an important role in the human metabolism. It is in particular known to act as a drug enhancer by increasing trans-membrane permeability, and as an anesthetic.... -
Neutron reflectivity study of bacterial lipopolysaccharide interactions with ...
Bacterial LPS (endotoxin) is a key determinant of host/pathogen interactions. We propose to investigate the role of membrane lateral phase separation on LPS insertion into model... -
Kinetics of amphotericin B interaction with model human and fungal cell membr...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents. The successful development of... -
Neutron Reflectivity study of lipopolysaccharide complexes with lateral domai...
We propose to investigate the role of lateral phase separation on LPS insertion into model membranes and the effects of target membrane structure and composition. A comparison... -
Water dynamics in porous PTFE membranes for water purification
This is a resubmitted proposal in a new project on water purification by membrane distillation. With this technology liquid water is excluded from passing the separating... -
Investigation of phase diagrams of polysaccharides
This project concerns fundamental and strategically important research underlying the development of new drug delivery vehicles. We propose to sample phase diagram of... -
Molecular interactions between phospholipid monolayers and dimethylsulphoxide
Neutron reflectivity will be employed to investigate the interaction between dimethylsulphoxide and monomolecular films of phosphatidylcholine. The monolayer will be used as a... -
Conformational changes on interaction of cytochrome c with lipid monolayers.
The main objective of the present work is to gain an understanding of the interaction of the cationic protein, cyt c with anionic lipid membranes. This objective will be... -
Self-Organisation of Phospholipids on Au Electrodes
This experiment is part of a programme to study the effect of applied electric fields on the structure of biomimetic films formed at Au electrodes, with emphasis on... -
Neutron reflectivity studies of the interaction of amphotericin with model ce...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin (AmB) has created a demand for novel anti-fungal agents that can circumvent the pathogens¿... -
Binding of DNA to Model Membranes in the Presence of Ca2+ Ions and a Membrane...
The aim of the present work is to gain an understanding of the interaction of DNA with the phospholipid bilayers. The effect of different forms of DNA, the presence of divalent...