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Characterisation of Hybrid Lipid-Polymer Nanoparticles
Hybrid lipid-polymer nanoparticles have demonstrated potential as drug delivery vehicles. The current proposal aims to use small angle neutron scattering (SANS) in combination... -
Molecular architecture of novel, trichain-containing vectors for gene delivery
We have recently developed novel ternary lipopolyplex vectors (i.e. gene delivery vectors containing cationic lipid, plasmid DNA and a cationic peptide) in which, for the first... -
Silica perturbation of the water structure around cationic micelles during te...
This proposal continues a new direction in our research on surfactant-templated inorganic materials. These nanostructured materials contain ordered arrays of surfactant micelles... -
Aggregation behaviour in solution of cationic conjugated polymers and oligomers
In the proposed experiments we extend previous work on characterization of aggregates formed by cationic conjugated polymers and oligomers in water. Particular emphasis will be... -
Adsorption of cationic surfactants to Al2O3
A recent experiment has provided clear evidence for a large maximum in the adsorption just below the critical micelle concentration of the surfactant hexadecyl trimethyl... -
Structural studies of mixed anionic and cationic surfactants at the charge me...
This proposal is concerned with the structural study of anionic and cationic surfactant mixture on a charged metal oxide surface using neutron reflectivity. Also to evaluate the... -
Micelle curvature effects on polyelectrolyte-surfactant film structures
This proposal continues our investigations into polyelectrolyte-surfactant thin films which form at the air-solution interface. Our previous work investigated structure... -
The effect of unsaturation on the shear dependence of cationic lamellar phase...
Products such as fabric and hair conditioners are commonly in the form of di-alkyl chain cationic lamellar phase dispersion. The effects of shear on such lamellar phase... -
The Interaction of Ammonia with Binary and Ternary Deuterides;
The interaction of ammonia with binary hydrides (prototypically, the interaction of LiH with ammonia gas) is thought to be the predominant interaction for hydrogen production... -
Effect of serum on the structure of gene delivery vehicles
To date complexes prepared from vesicles composed of dichain, cationic lipids (L) with negatively charged DNA (D), known as LD complexes have emerged as one of the major... -
Probing the kinetics of the formation of lipid, peptide and DNA/siRNA complex...
Complexes prepared from cationic, dichain lipid (L) vesicles, positively chargely targeting peptides (P) and negatively charged DNA (D) or siRNA (R), known as LPDs and LPRs... -
Curvature effects in polyelectrolyte-surfactant solution interactions
This proposal continues our investigations into polyelectrolyte-surfactant solutions which form thin films at the air-solution interface. Our previous work has investigated the... -
Validating calorimetric self aggregation models: Self aggregation of cationic...
Ligand self aggregation is a common problem when studying interactions with bio(macro)molecules. In particular for techniques requiring relatively high ligand concentrations,... -
Planar bilayer formation on novel cationic surface suitable for membrane prot...
Membrane receptor proteins (MRPs) which are thought to represent the majority of drug targets are challenging to study as their structure and function is dependent on being... -
Interactions between a mixture containing two cationic polyelectrolytes and a...
Recently there has been a vast expansion in understanding about the interactions between oppositely charged polyelectrolyte/surfactant mixtures. The use of neutron reflectometry... -
Encapsulation of monomers in cationic surfactant-polymer solutions
We have been studying the solution interactions leading to formation of solid polymer-surfactant films at the air-solution interface. We wish to use the mesostructures in the... -
vibrational spectroscopy of a novel dipalladium(I) hydride displaying dynamic...
Our report of a novel cationic dipalladium(I) hydride in (Angew. Chem. Int. Ed. 2010, 49, 6315) shows a linear Pd-Pd-H core with H-ligand dynamics (solution NMR). Ab-initio MD... -
Novel block bottlebrush polyelectrolytes: The effect of cationic block charge...
In this work we will study a novel block copolymers consisting of a linear cationic block and uncharged bottle-brush block having 45 units long poly(ethylene oxide) side chains.... -
Structure of siRNA containing delivery vehicles: effect of serum
Complexes prepared from cationic, dichain lipid (L) vesicles and negatively charged siRNA (R), with and without positively chargely targeting peptides (P) known as LR or LPR... -
Direct beam_TRANS
This dataset has no description
