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Temperature Effects and Kinetics of Thiolipid Adsorption to Gold Surfaces
We have a programme investigating the structure and function of protein scaffolds oriented on gold surfaces using sulfur chemistry for attachment. The aim is to direct the... -
Understanding the insertion of antibiotic toxins into the gram negative outer...
The gram-negative bacterial membrane is of extreme medical importance. Two of its major components are lipopolysaccharides (LPS's) and integral membrane proteins. Porins are... -
Outer membrane mimics using novel thiol-PC
We have recently shown that dense monolayers of PC can be assembled on gold surfaces using a new omega thiol PC from Avanti. This has two advantages over our previous methods.... -
Analysis of the Self-Assembled S-layer Protein SpbA on Silanised Planar Silic...
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Interaction between Rubisco and SDOBS at an air-water interface
Protein-surfactant interactions at an interface play an important role for broad applications in the chemical, dairy, cosmetic and pharmaceutical industries. Rubisco is the most... -
An immunoassay for the detection of IGFBPs: surface characterisation
Summary: The FIII9'10 domain pair is an antibody light chain mimic which we serendipitously found binds IGFBP-5, a therapeutic target in late stage prostate cancer. An... -
Protein secretion: Studying the folding and assembly of membrane proteins usi...
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Neutron Reflectivity Study on Multi-domain DNA Molecular Motors
DNA is a versatile building material for nanotechnology. We have recently studied a surface-tethered single-domain DNA motor by neutron reflection (IR) for the first time. We... -
A Reversible pH-Driven DNA Nanoswitch
DNA is an extremely versatile building material for the development and assembly of functional nanostructures and nanodevices. There are numerous examples of DNA based... -
Oriented antibody binding layers
The proposal concerns the assembly of high density antibody binding surfaces to increase the sensitivity of medical diagnostics. Previously we showed that antibody binding... -
Characterisation of bioadhesive protein-PEG conjugates grafted to titanium su...
Summary: Titanium implants are surgically important and require a hydrophilic polymer coating to prevent biofouling in situ. Bioadhesive proteins can be covalently tethered to... -
Structure and activity of Membrane Proteins immobilised to solid supports.
Membrane Proteins (MPs) consist of about 1/3 of the proteome but the structural information available is very limited compared to that for soluble proteins. Despite this at... -
Determining the structure of the colicin OmpF complex
Large multiprotein complexes are the new frontier in structural biology. Individual proteins may be solved by X-ray crystallography but the relationships between subunits and... -
More realistic models of the bacterial outer membrane
Current model systems employed in structural studies of bacterial outer membranes rarely mimic the lipid composition accurately. This work is aimed at producing outer membrane... -
Reflectometry studies of the mechanism of formation of mesoporous silicate fi...
Surfactant-silica self-assembly processes have been extensively studied since the discovery of M41S mesoporous materials in 1992. Mesoporous silicate films can be grown from... -
The solution structure of the OmpF¿Colicin N complex in lipid nanodiscs
We have previously solved the structure by SANS of the complex between the outer membrane protein F of E coi and the toxin colicin N which is a large antibiotic protein. This... -
Organisation of Outer membrane protein F at the air/liquid interface
Crystallisation of membrane proteins as a precursor to high resolution structural studies is a significant research bottleneck. We are investigating alternative methods to... -
Floating Lipid Bilayers Created by Vesicle Fusion
'Floating LSupported Bilayers' (FSB's) have become the 'standard' systems used for studying membrane systems using reflectivity at ISIS and other facilities. They are reliable,... -
Single Domain pH-Driven DNA Nanoswitch
DNA is an extremely versatile building material for the development and assembly of functional nanostructures and nanodevices. There are numerous examples of DNA based... -
Structural characterisation of vaccine-adjuvant interactions using neutron re...
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