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Probing the Kinetics of Assembly and Triggered Dispersion of Peptide-Function...
Peptide-functionalized nanoparticle (NP) aggregates have significant potential as biosensors (for specific enzymes) due to their high sensitivity, modular design and simple... -
Structure in "Microemulsions behaving badly"
An unusual set of systems, displaying key characteristics of microemulsions have been discovered using highly branched chain anionic surfactant stabilizers (Figure 1).... -
Study of self-organization of cationic pH- and thermo responsive copolymers w...
The aim of our work is to study structural properties of supra-molecular assemblies formed in aqueous solutions of cationic pH- and thermo-sensitive block-gradient copolymers... -
Self-assembling behaviour of N-acyl amino acid-based surfactants
N-acyl amino acids are surfactants with attractive applications in different technological fields. They are referred to as mild surfactants because they are commonly considered... -
Complex evolution of solution microstructure in LAS / nonionic surfactant mix...
This proposal is part of a broad programme of collaborative research between RAL / Oxford and Unilever, using predominantly scattering techniques to investigate the nature of... -
Solution structures of the immunologically important proteins IgA and C3b
We are unravelling the solution structures of the Fab and Fc fragments in the IgA antibody family important in mucosal immunology. Having completed the structures for IgA... -
Kinetics of amphotericin B interaction with model human and fungal cell membr...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents. The successful development of... -
Viscosity modifiers for CO2
There is a well-documented track record of research into water-in-CO2 (w/c) microemulsions. Using newly discovered CO2 compatible surfactants, the next step is to explore... -
Novel gels with supercritical carbon dioxide
This proposal is to probe the gel structure with High Pressure SANS (HP-SANS) using an in-line pressure cell. The ability to control the properties of supercritical CO2,... -
Magnetic nanostructures of Fe-Ag and Fe-Au granular thin films
Nanogranular thin films of FexM100-x (M=Au,Ag; x=7,20,39) are an excellent system to study the magnetism of nanoparticles in diamagnetic matrices coupled by direct, RKKY and... -
Polymer conjugates for drug delivery
Complex polymer architectures such as comb polymers have been studied for their highly customisable chemical properties. Potential applications have been identified in a wide... -
Changes of phospholipid aggregate morphology induced by phospholipase hydrolysis
We propose to look at the interaction of the aggregates two phospholipids form with two phospholipase (PL) enzymes, PLA2 and PLC, which hydrolyse different ester groups in the... -
Is there a CMC for surfactants in non-aqueous solvents?
The aim of this project is to use SANS to determine if a critical micelle concentration (CMC) exists for the formation of inverse micelles in non-polar solvents. The CMC is a... -
Bi-disperse colloids: silica and microemulsions
Surprisingly little work has been done to gain understanding about the nature, stability and properties of nanoparticles dispersed in organic solvents (organosols). Recently... -
Adsorption of of hydrophobin and hydrophobin / surfactant mixtures at the oil...
Hydrophobins are secreted fungal proteins and are small lipopeptide biosurfactants. They are strongly surface active and self-assemble at interface, and these unique film... -
A structural evolution: hydrotrope-alkyl hydrotrope-surfactant
The aim of the proposal is to improve understanding about combinations of normal surfactants and hydrotropes. The systems of study are reference oil-water interfaces, provided... -
Mixed surfactants for dialable organogels
The idea is to be able to ¿dial-up¿ the length and properties of CO2-philic and organo-philic rod-like micelles. This proposal aims to explore mixed surfactant systems in... -
SANS experiments on phase separation in Fe-Cr based alloys
Low temperature embrittlement of stainless steels is due to phase separation and in this proposal we will further investigate the underlying mechanisms for phase separation.... -
Mixed micelles with green surfactants
This proposal aims to explore aqueous phase structures and compositions of a series of mixed surfactants. Although standard petrochemically-derived surfactant mixtures have been... -
Aggregate structures formed by lipopolysaccharide-peptide complexes in solution
Bacterial lipopolysaccharide (LPS) is a bioactive structural amphiphilic molecule which forms the outer leaflet of the outer membrane of the Gram negative cell envelope. During...