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Study of protein adsorption tuned via multivalent ions and the influence of s...
Protein adsorption at solid-liquid interfaces plays a key role in biomedical technologies such as biosensors or biomaterials for medical implants. Despite considerable progress... -
Novel block bottlebrush polyelectrolytes: The effect of cationic block charge...
In this work we will study a novel block copolymers consisting of a linear cationic block and uncharged bottle-brush block having 45 units long poly(ethylene oxide) side chains.... -
Steroidal drug containing dodecyl sulphate monolayers: effect of counterion
An number of potential drugs, including steroidal drugs are extremely water insoluble, limiting their commercialisation as medicines. Solubilisation of drug in surfactant... -
Effect of polar solvent on the structure of monolayers of phospholipid
It is the aim of the proposal is to perform neutron reflectivity (NR) studies combined with contrast variation to determine the structure of phospholipid monolayers on a... -
Adsorption of organics at the calcite/oil interface and the role of water
This proposal will exploit the unique ability of neutron reflection to characterise the adsorption of a key additive on the surface of calcite from a non-aqueous solvent and the... -
Surface Smectic Layers in difluoroterphenyls
The proposal is to use previous established neutron reflection methods to observe the smectic layers that form at the surface of a nematic liquid crystal. In this proposal we... -
Tuneable Creation of Reservoir Structures at the Air/Water Interface
Recently we have exploited non-equilibrium effects in the preparation of super-efficient polyelectrolyte/surfactant films at the air/water interface spread from the dissociation... -
Mixed Amino-Acid Based Surfactant Monolayers
Amino acid based surfactants have been known for many years but so far few detailed studies have been carried out on their properties. We are using amino acids extracted from... -
Adsorption of nanodics (stabilised by sytrene-maleic anhydride derived copoly...
Nanodiscs are self-assembled structures that consist of a bilayer of phospholipids controlled in diameter by a polymer or protein belt. We have already shown that such discs... -
Amino-Acid Based Surfactant Monolayers on a Range of Subphases
Amino acid based surfactants have been known for many years but so far few detailed studies have been carried out on their properties. We are using amino acids extracted from... -
The structure and orientation of the Bam complex in the Gram-negative outer m...
The proteins of the outer membrane of Gram-negative bacteria are critical for bacterialsurvival, from providing basic physiological functions, to aiding virulence and... -
The Orientation and Conformation of an Enantiomeric Pair of 310 Helical Pepti...
We wish to investigate the interactions between peptide mimics of peptaibols, a highly active class of natural antimicrobial peptide, and membranes. In particular we are... -
Surface charge induced layering of ionic liquids on mica
The structure of ionic liquids at charged interfaces is an exciting and vibrant area of current research. Previous surface force apparatus experiments have shown layering up to... -
Proving ground-state ordering in Artificial Spin-Ice systems formed by sub-10...
The main purpose of the experiment proposed here is to study the effects of thermalisation on Artificial Spin-Ice (ASI) systems formed by nanomagnets with sub-100 nm lateral... -
Antibody-polysorbate surface interactions
Of concern to the bioprocessing industry is the manner in which polysorbates included in solution formulations of antibodies affect the kinetics and equilibrium state of... -
Novel Alginate Adsorption onto High Surface Energy Crystal Faces of Calcite
In this novel proposal we will investigate adsorption onto the non-equilibrium face of calcite the first time this has been attempted. This will compliment and extend our... -
Assessing the interactions of cyclic peptide-polymer conjugates with a lipid ...
Cyclic peptide-polymer nanotubes can readily self-assembly into long nanotubes, and are being extensively studied for drug delivery applications. As such, understanding how... -
Effect of alkyl chain length on the adsorption of n-alkyl phosphocholine surf...
This proposal relates to the study of adsorption of n-dodecyl phosphocholine (C12PC) at the oil-water interface. The thickness of the adsorbed monolayers measured for dC12hPC... -
A biophysical approach of studying the molecular interactions of a novel anti...
Gram negative (-ve) bacteria possess numerous defenses against antibiotics, not the least of them being the intrinsic permeability barrier afforded by their outer membrane (OM)... -
Impact of Elasticity on Surface Wetting
We have recently characterised a surface wetting transition for a low molecular weight oligomer in a high molecular weight rubbery polymer. Although weak surface segregation of...
