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A Reversible pH-Driven DNA Nanoswitch
DNA is an extremely versatile building material for the development and assembly of functional nanostructures and nanodevices. There are numerous examples of DNA based... -
Neutron Reflectivity Study on Multi-domain DNA Molecular Motors
DNA is a versatile building material for nanotechnology. We have recently studied a surface-tethered single-domain DNA motor by neutron reflection (IR) for the first time. We... -
Effects of Architecture on Polymer Diffusion
As part of a wider study we are studying the effects of polymer architecture between cyclic and linear polymers. From ATR-FTIR measurements we observe clear differences between... -
Examination of the Membrane Structure of Live Bacteria using Neutron Reflecto...
We propose to investigate in-vivo cell membrane structure of gram-positive (B. subtilis) and gram-negative (S. oneidensis) bacteria adhered to a silicon oxide surface using... -
Adsorption and activity of Thermomyces lanuginosus Lipase (TLL) at the oilwat...
The purpose with the proposed project is to provide a better understanding of structural changes in interfacial lipid layers due action of lipolytic enzymes. In this study we... -
The Mechanism and Kinetics of Lipid Flip-Flop in Floating Phosphatidylcholine...
In order to maintain their asymmetric lipid distribution, cellular membranes have a number of means to translocate lipid molecules across the bilayer. On top of the well-studied... -
Further Studies on the Gating Mechanism of an Antimicrobial Peptide Using Con...
Antibiotic peptides are generally small, simple, usually alpha-helical peptides, which nevertheless show quite complex biological behaviour. We have been studying the gating... -
Nanodiscs films at the air-water interface
Nanodiscs are self assembled complexes of phospholipids and a class of amphipathic helical proteins termed membrane scaffold proteins . The proteins and lipids self-assemble... -
Competitive adsorption in hydrophobin / protein mixtures at the solid-solutio...
Hydrophobins are secreted fungal proteins in the form of small lipopetide biosurfactants. They are strongly surface active and self-assemble at interfaces and in solution. This... -
Probing perfume surface delivery / retention rates in-situ
This proposal is part of a funded (CASE) project, aimed at understanding the delivery of benefit actives (perfumes) to interfaces and the development of new self-assembled... -
Multilayer formation at the air-water interface in polyamine / surfactant mix...
The spontaneous formation of multilayer structures at interfaces by surfactant self-assembly is emerging as an important and more common structural signature associated with a... -
Probing the effects of oxidative stress on the membrane binding of alpha-synu...
Neutron reflectometry will be used to characterise the cellular membrane binding interaction of alpha-synuclein under conditions mimicking oxidative stress. Alpha-synuclein is... -
Adsorbtion from nematic mixtures
The aim is to measure the preferential adsorption of one component in a nematic mixture. The base is 4-pentyl 4¿- cyanobiphenyl (5CB) and it is doped with 4-pentyl 4¿-... -
The effect of dendrimer surface functionalization on the interaction with mod...
Dendrimers are a unique class of nano-structured vehicles for drug and gene delivery into intracellular targets. Their surface chemistry influences their transport across... -
Effect of membrane fluidity for novel dendrimer drug interaction and uptake m...
Bacteria growing resistant to common antibiotics is a growing problem and research in new types of medicines which do not induce resistance is therefore very important. Novel... -
Adsorption of cationic surfactants to Al2O3
A recent experiment has provided clear evidence for a large maximum in the adsorption just below the critical micelle concentration of the surfactant hexadecyl trimethyl... -
Surfactant adsorption onto model surfaces
In the context of home and personal care products, studying surfactant and mixed surfactant adsorption ion model solid surfaces, which mimic real surfaces such as fabrics, hair... -
Neutron reflectivity of self-assembled Janus Nanoparticles
Here we propose to study the Janus character of self-assembled amphiphilic nanoparticles. For that amphiphilic core-shell nanoparticles will be synthesized with a surface... -
Competetive adsorption in hydrophobin / protein mixtures at the air-solution ...
Hydrophobins are secreted fungal proteins in the form of small lipopetide biosurfactants. They are strongly surface active and self assemble at interfaces and in solution. This... -
Kinetics of surfactant multilayer formation / dissolution at interfaces
The formation of multilayer structures at surfaces and interfaces from self-assembly in mixed surfactant and in polymer / surfactant mixtures has been recently reported, and...
