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Error correction tool benchmark
This project compares the performance of different hybrid error correction tools. -
BAMBI__Baby_Associated_MicroBiota_of_the_Intestine_
Study to characterise the microbiota of preterm infants over time These data are part of a pre-publication release. For information on the proper use of pre-publication data... -
microbial community diversities of soil Raw sequence reads
A field study was carried out to analyze the short-term effects of organic and inorganic fertilizers on microbial community relevant to soil fertility in terraces on the Loess... -
Yellowstone Carcass Metagenome
We assessed how predation by large carnivors affects soil properties and ecosystem functioning by altering microbial (bacteria, fungi) biodiversity and community composition. We... -
The stress granule transcriptome reveals principles of mRNA accumulation in s...
Stress granules are mRNA-protein assemblies formed on nontranslating mRNAs. Stress granules are important in the stress response, related to neuronal mRNP granules, and aberrant... -
Origin and Evolution of Neural Microexons
Our study focuses on the origin of the neural microexon program.</p><p>We discover that neural microexon programs are present in non-vertebrate... -
Large scale metagenome assembly reveals novel animal-associated microbial div...
Large-scale metagenome assemblies of human microbiomes have produced a huge catalogue of previously unseen genomic data, but has been applied to only a few of the >66 000... -
Genome-wide determinants of sequence-specific DNA binding
DNA binding protein are generally thought to bind specific DNA sequences through selective interactions with DNA bases. However, it is now becoming more widely appreciated that... -
Eukaryotic-driven directed evolution of Cas9 nucleases
Further advancement of genome editing highly depends on the development of tools with higher compatibility with eukaryotes. A multitude of described Cas9s have great potential... -
Simul-seq Method
Paired DNA and RNA profiling is increasingly employed in genomics research to uncover molecular mechanisms of disease and to explore personal genotype and phenotype... -
Fully defined human PSC-derived microglia and tri-culture system reveals cell...
Aberrant inflammation in the central nervous system (CNS) has been implicated as a major player in the pathogenesis of human neurodegenerative disease. However, the specific... -
Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping
N4-acetylcytidine (ac4C) is an ancient and highly conserved RNA modification, present on tRNA, rRNA and recently investigated in eukaryotic mRNA. We report ac4C-seq, a chemical... -
Decoding Epitranscriptional Landscapes form Native RNA Sequences
The procedure combined with the specifically developed bioinformatic tool ELIGOS (Epitranscriptional Landscape Inferring from Glitches of ONT Signals) was used to identify RNA... -
MinION DNA barcoding of five representative species
To test the accuracy and the efficiency of DNA barcoding with MinION nanopore we amplified the relevant barcode regions from the genomic DNA of five representative species... -
Sequencing short capped RNAs captures acute transcription initiation and iden...
The spatial and temporal regulation of transcription initiation is pivotal for controlling gene expression. Here, we introduce capped-small RNA-seq (csRNA-seq), which uses total... -
Single-Base Resolution Mapping Reveals Distinct 5-Formylcytidine in Saccharom...
5-Formylcytidine (f5C) is one type of post-transcriptional RNA modifi-cations, which is known at the wobble position of tRNA in mitochon-dria and essential for mitochondrial... -
Identification of exceptionally potent adenosine deaminases RNA editors from ...
The most abundant type of RNA editing in Metazoa is the deamination of adenosine to inosine, A to I, catalyzed by ADAR enzymes, double strand specific deaminases. Inosines are... -
HIV-1 RNA structure and heterogeneity analysis
The goal of this set of experiments is to determine the structure of HIV-1 NL4-3 and NHG RNA structure using a novel algorithm that allows for the identification of multiple RNA... -
Mobility based deep sequencing of 4 RNA targets
Mobility based deep sequencing of 4 RNA targets, which includes 2 riboswitches, 1 ribozyme and 1 xrRNA -
SHAPE analysis of RNA structure in living cells with unprecedented accuracy
Due to the mounting evidence that RNA structure plays a critical role in regulating almost any essential physiological as well as pathological process, being able to accurately...