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Oxidative stress and lipid membrane disruption in bilayers containing polyuns...
Oxidation of lipid membranes is widely known to play a crucial role in many cellular processes and pathological conditions such as apoptosis, inflammation, infection, or sepsis,... -
Determination of the absorbed amount and location of a hydrophobic drug in su...
Many drugs are both poorly water-soluble (hydrophobic) and lipophilic in nature and are therefore incorporated into surfactant micelles and monolayers. As the incorporation of... -
Ibuprofen containing surfactant monolayers: location and stiochiometry of ibu...
An increasing number of potential drug molecules are extremely water insoluble, limiting their commercialisation as medicines. Solubilisation of drug in surfactant micelles is a... -
Deposition of lipid bilayer through peptide-discs
We are developing a new protocol for the preparation of lipid bilayers suitable to host membrane proteins with control on their orientation. Our proposed strategy is based on... -
Do cardiolipins play a role for the mode of action of antimicrobial peptides?...
Antimicrobial peptides (AMPs), also called host defense peptides, are part of the innate immune system of essentially all species, from bacteria themselves to mammals to protect... -
Purothionin binding to model fungal lipid membranes
Purothionins and defensins are basic, amphiphilic, cysteine-rich and low molecular weight plant defence proteins. These proteins are active against a broad range of... -
The use of lipid sponge-like nanoparticles as carriers for macromolecules and...
Conventional ways to administer and deliver drugs have reached its limitations. These methods can be still used for small and simple molecules. However, new carriers have to be... -
Neutron scattering to characterise protein interactions with solid-liquid int...
Objectives of this proposal aim to shed light on how adsorption processes such as protein A chromatography, used to purify biologics, affect protein propensity for aggregation.... -
Examination of the Membrane Structure of Live Bacteria using Neutron Reflecto...
We propose to investigate in-vivo cell membrane structure of gram-positive (B. subtilis) and gram-negative (S. oneidensis) bacteria adhered to a silicon oxide surface using... -
An immunoassay for the detection of IGFBPs: surface characterisation
Summary: The FIII9'10 domain pair is an antibody light chain mimic which we serendipitously found binds IGFBP-5, a therapeutic target in late stage prostate cancer. An... -
Cationic surfactants adsorbed to titanium dioxide-effect of pH and added elec...
Titanium dioxide (TiO2) is used in a wide range of applications from medical and dental implants to treatment of contaminated air and water streams. However many of the... -
Probing the interactions of chitosan with lipid bilayers to elucidate its ant...
Chitosan is a linear polysaccharide that is biocompatible and biodegradable. Chitosan has a number of unique chemical and biological features including its cationic nature and... -
Acid /amine complexation on an iron oxide /Oil interface
This experiment seeks to characterise the monolayer composition and structure of binary mixtures of fatty acid and amine. This represents a key additive system used commercially... -
Understanding Surfactant-Semiconducting Polymer Interactions for Optimisation...
This dataset has no description
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Humic acid interactions with alumina surface and the effect of perfluoroalkyl...
In the soil environment, organic matter such as humic acid has a strong influence on the behaviour of organic pollutants such as perfluoroalkyl substances (PFASs) and their... -
Adsorption of bioengineered antibodies at the oil/water interface
Following our previous study of interfacial adsorption of the basic version mAb COE-3, we wish to continue this work by exploring how two modified mAbs adsorb at the same... -
Assembling Biomimetic layers on monolayers of Gold Nanoparticles
Gold provides a high quality surface on which to arrange biomolecules such as proteins since we can use cysteine amino acids to deliver gold thiol chemical bonds which can... -
Interaction between Rubisco and SDOBS at an air-water interface
Protein-surfactant interactions at an interface play an important role for broad applications in the chemical, dairy, cosmetic and pharmaceutical industries. Rubisco is the most... -
Effect of saponin-rich plant extracts on skin-mimicking model lipid bilayers
Plant-derived biosurfactants of the group of saponins offer an attractive alternative to synthetic surfactants because of their unique foaming and emulsifying properties... -
Satisfying the need for contrast in antimicrobial research
Gram-negative bacteria, which cause a variety of diseases including meningitis, plague, sepsis and food poisoning, are becoming increasingly antibiotic resistant. One reason is...
