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Substrate-dependent structure of thin hydrogel films
Hydrogels are water-rich polymer networks made from natural or synthetic polymers, which are widely used in biomaterials, medicine and antifouling. We have developed PEG-based... -
Recreating the specific colicin NRa-LPS interaction in a model bacterial out...
The Gram negative bacterial outer membrane protects the bacterium from external toxins such as antibiotics. This is partially responsible for Gram negative bacteria becoming the... -
Hydrophilic Melt Additive Segregation in Polyolefins
Small molecule additives are used in melt processing, sometimes to lubricate extrusion or to provide bespoke hydrophilic surfaces. Both applications require the additive to... -
Tuning the Magnetic Properties of γ-Fe2O3 Fe3O4 Thin Films for Atom Tr...
In this work we will investigate how the magnetic properties of nanometer thick iron-oxide films can be manipulated by heating them in air. Our preliminary results indicate that... -
The mechanism of lipid transport in Gram-negative bacteria
The bacterial cell envelope is one of the best targets for antimicrobial development. It is this envelope that harbours the instruments of microbial warfare, preventing its... -
Ion distribution in light-emitting electrochemical cells
Semiconducting polymers are researched as alternatives to inorganic materials for use in electronic devices, such as solar cells or organic light-emitting diodes. Polymers are... -
Interactions between lipoprotein particles from human serum and model blood v...
In westernised societies, atherosclerosis and its clinical consequences such as heart disease and stroke constitute the leading cause of death. Thus, the prevention or... -
Self-assembling antimicrobial peptides: interactions with model lipid membranes
We propose to investigate antimicrobial peptides that self-assemble into well-defined nanostructures. Previous SAXS results have shown that the peptides form rather robust... -
Protein Adsorption at the PDMS Oil/Water Interface
Neutron reflection has been successfully used to measure the conformation of proteins adsorbed at the oil/water interface. However, in several such experiments, hexadecane has... -
Self-assembled Floating Lipid Bilayers: What Forces Are Causing the Bilayer t...
Recently (RB19100102) we have discovered that floating bilayers composed of fluid phase lipids can be produced by deposited vesicles onto charge modified oligo(ethylene... -
Neutron scattering to characterise protein interactions with solid-liquid int...
Objectives of this proposal aim to shed light on how adsorption processes such as protein A chromatography, used to purify biologics, affect protein propensity for aggregation.... -
Adsorption of key functionality at the calcite/water interface
Calcium carbonate is one of the most abundant minerals at the Earths surface and plays a large role in the chemistry of aquatic environments, as well as being the main... -
Introducing the O-antigen into Bacterial Outer Membrane Models
The Gram negative bacterial outer membrane protects the bacterium from external toxins such as antibiotics. This is partially responsible for Gram negative bacteria becoming the... -
Nanoparticle-surfactant layers at the water-oil interface
The spontaneous selfassembly of nanoparticles (NP) at liquid-liquid interfaces is a phenomenon present in nature and relevant for many applications, such as, emulsion... -
Elucidating molecular mechanism of membrane disruption by designed α-hel...
We have previously shown that peptides such as G(IIKK)4I-NH2 (G4) can kill bacteria and inhibit cancer cell growth whilst remaining benign to mammalian host cells. We have also... -
The Interaction of wild-type and mutant Puroindoline B with Model Bacterial M...
Bacterial and fungal infections of cereal crops pose considerable risk to food security. Pathogenic resistance to conventional fungicides and pesticides is becoming widespread... -
Adsorption of Organic Phosphate onto Silicon
This proposal presents to directly measure ¿bridging¿ of anionic surfactants on an anionic surface through multivalent ions from water under well-controlled conditions (pHs and... -
Quasi-elastic neutron scattering using Neutron Spin echo
We propose a measurement of the effectiveness of using the RF flippers on Offspec in a quasi-elastic mode (theta=90°) with the RF at 0.5MHz. This is important to our future... -
Neutron reflection studies on model wax films reconstituted from chemicals
Morphological features of plant waxes vary from species to species, but little is understood about what controls these morphological changes although it is widely believed that... -
Neutron reflection study of spin coat grapheme oxide films
We have recently been able to form a thin graphene oxide (GO) film with uniform thickness around 30±2Å from aqueous GO suspensions by spin coating (onto small wafers for...
