146 datasets found

An number of potential drugs are extremely water insoluble, limiting their commercialisation as medicines. Solubilisation of drug in surfactant micelles is a means of increasing...

The aim of this proposal is to study the internal structure of novel organometallic polymers based on two metal-containing moieties -Ru, Au (or Ag)- bridged through a tridentate...

We have recently shown that acid washing of a carbon support prior to metal (Au, Pd) deposition enhances the activity of the resulting catalysts for the direct synthesis of...

The aim of the proposal is to improve understanding about combinations of normal surfactants and hydrotropes. The systems of study are reference oil-water interfaces, provided...

Large multiprotein complexes are the new frontier in structural biology. Individual proteins may be solved by X-ray crystallography but the relationships between subunits and...

Current model systems employed in structural studies of bacterial outer membranes rarely mimic the lipid composition accurately. This work is aimed at producing outer membrane...

The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the...

Hydrophobins are secreted fungal proteins and are small lipopeptide biosurfactants. They are strongly surface active and self-assemble at interface, and these unique film...

Third Generation Advanced High Strength Steels (AHSS) require higher strength and formability alongside a lower alloying element content for reduced energy consumption and CO2...

We plan to carry out SANS experiments on a bacterial colonization factor to elucidate how it interacts with chitin, which is found on the surface of plankton and crustaceans....

Despite interest in microemulsions as drug delivery vehicles, there is a lack of structural understanding to justify the formulations used. The present study examines the use of...

This proposal seeks to identify and characterise high-pressure polymorphs of the energetic materials hydroxylammonium perchlorate, CL-20, diaminodinitroethene (FOX-7), and...

This proposal focuses on a new approach to the formation of rod-like micelles in supercritical CO2 (scCO2). Recent successful high-pressure SANS (HP-SANS) results have shown for...

The aim of this experiment is to explore a very recent discovery made by ourselves that shear flow can suppress the nucleation and growth of crystals of specific low molar mass...

This proposal aims to combine the approaches of several successful recent neutron reflection studies by our group to directly measure ion layering at electrode surfaces. In this...

In a pharmaceutical industry context, hydrophilic polymeric matrices are a popular methodology for extending the release of drugs. However, issues sometimes arise -...

Surfactant-silica self-assembly processes have been extensively studied since the discovery of M41S mesoporous materials in 1992. Mesoporous silicate films can be grown from...

We propose to look at the interaction of the aggregates two phospholipids form with two phospholipase (PL) enzymes, PLA2 and PLC, which hydrolyse different ester groups in the...

This proposal aims use a novel approach whereby deuterated amyloid peptide fibrils are givenhydrogenated growing ends, and analysed using SANS. The data will enable us to...

This proposal seeks to identify and characterise high-pressure polymorphs of the energetic materials hydroxylammonium perchlorate, CL-20, diaminodinitroethene (FOX-7), and...