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SANS study of hollow nanoparticles and their solvent release
Hollow nanoparticles (HNP) have been successfully used for encapsulation and controlled release of biochemicals such as drugs, DNA, and dyes. However no in-situ method has been... -
Dynamics of amyloid protein fibril growth using isotope-labelled SANS
This proposal aims use a novel approach whereby deuterated amyloid peptide fibrils are givenhydrogenated growing ends, and analysed using SANS. The data will enable us to... -
On the peculiarities of the structure of particle stabilised foam
Many formulated products pass through or end up as foams, comprising immiscible millimeter sized bubbles dispersed into an aqueous continuous phase. Frequently, surfactants or... -
A SANS Study of Hydration Shell and Magnetic Field Alignment of Amyloid Pepti...
We will perform neutron scattering experiments (SANS) to probe the mechanism of alignment of amyloid peptides on drying in the presence of a 2T magnetic field, as well as the... -
Dynamics of amyloid protein fibril elongation using isotope-labelled SANS
This proposal combines optical spectroscopy with neutron scattering using novel labelling strategies to investigate ?amyloid? protein fibrils. Variations in packing and in the... -
Interaction of keratin with surfactants studied by SANS
This proposal constitutes part of our ongoing study towards understanding how keratin, an important protein component of hair and skin, interacts with ionic surfactants using... -
SANS studies of mixed phospholipid:sterol vesicles and their interaction with...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
Water-based gels of half N-acetylated chitosans; potential pharmaceutical exc...
These experiments are part of a much broader programme at the University of Reading. focused on the use of water-soluble half-acetylated chitosan as a mucoadhesive polymer,... -
Development of Creep Cavitation in Stainless Steel
Reheat cracking is a creep failure mode that has been observed in welded structures operating at high temperatures in the power generation industry. The failure results from the... -
Probing the internal structure of gene delivery vehicles using contrast varia...
Gene delivery vehicles, known as LPD complexes, prepared from mixing cationic lipid vesicles (L) with cationic peptide (P) and DNA (D) have proven to be very effective at... -
Biomolecular Cryoprotection in Deep Eutectic Solvents
Protecting biomolecules, such as proteins and enzymes, from the effects of cooling and freezing is important for the storage and handling of pharmaceuticals. Deep eutectic... -
Lipid mesophase alignment induced by nanoparticles: Mesophase determination a...
At a recent experiment at the ILL using D22, we made an incidental observation that addition of hydrophilic silica (SiO2) nanoparticles (NP; D~14 nm) induced alignment in the... -
Binary colloidal mixtures - SANS contrast variation to study high concentrati...
Mixtures of colloidal particles of essentially two different sizes are commonly used in technological applications such as film formation on surfaces, paper coatings, etc.... -
Interaction of polypeptide with surfactant: SANS study of solution aggregation
This proposal constitutes part of our ongoing study towards understanding the solution aggregation of collagen based polypeptides and their interactions with model surfactants.... -
Insight into the atomic and intermediate level structure of spherical and rod...
Here we propose to look at the structure of two phosphocholine lipids, and their larger scale structures in aqueous solution. Depending on the length of the fatty acid chain in... -
Kinetics of amphotericin B interaction with model human and fungal cell membr...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents. The successful development of... -
Solution aggregation of lipopeptides: SANS structure determination
Lipopeptide surfactants are highly effective at reducing interfacial tension. However, there is a general lack of understanding of the relationship between their molecular... -
SANS Investigation on Packing Structure of Proteasome Activator 28
Proteasome plays an important role in the processing of antigenenic proteins for presentation by the MHC class I pathway. PA28 is an activator of the 20S proteasome, a large... -
Investigation of asphaltene nanoaggregate size under conditions of CO2 reserv...
The asphaltene fraction of crude oil is defined by its solubility parameters (insoluble in n-heptanebut soluble in toluene). Changes in conditions (temperature, pressure,... -
Micellization in glycerol:choline chloride deep eutectic solvent
Deep Eutectic Solvents (DES) are molecular mixtures with melting points below room temperature. DES share many features of ionic liquids (low vapour pressure, adjustable...