A SANS Study of Hydration Shell and Magnetic Field Alignment of Amyloid Peptide Fragments

DOI

We will perform neutron scattering experiments (SANS) to probe the mechanism of alignment of amyloid peptides on drying in the presence of a 2T magnetic field, as well as the initial hydration state of the fibrils via H2O/D2O contrast varation experiments. Magnetic field alignment has previously been shown to generate high quality x-ray fibre diffraction patterns, however the mechanism of orientation is not understood. Neutron scattering also offers the ability to study the hydration shell around the peptide fibrils. These studies will enable a deeper understanding of the structure of fibrils based on model amyloid peptide fragments currently under study in the Hamley group.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24088258
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24088258
Provenance
Creator Professor Ian Hamley; Dr Valeria Castelletto; Mr Ashkan Dehsorkhi; Dr Dmitry Stetsenko
Publisher ISIS Neutron and Muon Source
Publication Year 2014
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2011-12-01T09:02:53Z
Temporal Coverage End 2011-12-04T16:55:00Z