612 datasets found

Lipoproteins are the main carriers of lipids in the body. HDL is believed to favor cholesterol removal and decrease the risk to develop atherosclerosis and related...

In bacteria, mechanosensitive ion channels such as MscL protect cells against osmotic shock, but, as with all ion channels, they have the potential to act as an Achilles heel,...

Previously we have examined the interaction of barley non-specific lipid transfer protein (nsLTP1) with OTS and lipid monolayers at the solid/liquid interface. Examining the...

In the context of a project in collaboration with ISIS that focuses on structural studies under mechanical confinement, with a specific focus on biological lubricants, the...

Hydrophobins, hfb2, are secreted fungal proteins in the form of a small lipopeptide. They are strongly surface active and self-assemble in solution and at interfaces. They have...

Water-soluble conjugated polymers (WSCP) are an important class of materials which have received great attention as active materials in optoelectronic devices and in biosensing....

We propose to use SANS to probe the self organised formation of P3HT nanowires in a solution of deuterated chlorobenzene over a 48 hr period in order to better understand the...

Nearly 40% of new chemical entries are poorly water-soluble. Drug encapsulation into water-soluble polymers is an active research area owing to the ability of improving drug...

The pharmaceutical industry has been described as being 'in a period of crisis' as the number of drug approvals relative to most major pharmaceutical companies Research and...

The proteins of the outer membrane of Gram-negative bacteria are critical for bacterialsurvival, from providing basic physiological functions, to aiding virulence and...

Gram-negative bacteria, which cause a variety of diseases including meningitis, plague, sepsis and food poisoning, are becoming increasingly antibiotic resistant. One reason is...

Myelin is the multilamellar structure that ensheaths axons and accelerates nervous impulses in the nervous system. The fine structure of myelin remains to be further...

The global increase of bacterial resistance to antibiotics has led to increasing interest in research focusing on the development and characterization of new antimicrobial...

Polymer/fullerene blends represent the most common form of organic solar cell. This proposal forms part of a wider effort in which our motivation is to complement solar cell...

Hydroxyl radicals may be used as disinfection agent in the advanced oxidation processes or tertiary treatment of waste and occasionally drinking water. In this exploratory work,...

The Gram negative bacterial outer membrane protects the bacterium from external toxins such as antibiotics. This is partially responsible for Gram negative bacteria becoming the...

Small molecule additives are used in melt processing, sometimes to lubricate extrusion or to provide bespoke hydrophilic surfaces. Both applications require the additive to...

The bacterial cell envelope is one of the best targets for antimicrobial development. It is this envelope that harbours the instruments of microbial warfare, preventing its...

We propose to investigate antimicrobial peptides that self-assemble into well-defined nanostructures. Previous SAXS results have shown that the peptides form rather robust...

Neutron reflection has been successfully used to measure the conformation of proteins adsorbed at the oil/water interface. However, in several such experiments, hexadecane has...