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Molecular architecture of monolayers formed by novel sterol-modified phosphol...
A family of sterol-modified glycerophospholipids (SML) have been synthesized in which the sn-1 or sn-2 position is covalently attached to cholesterol and the alternative... -
Effect of oxidative stress on polyunsaturated lipid bilayers modulated by cho...
The exposure of biological membranes to reactive oxygen species is key for many pathological conditions, including inflammation, infection, or sepsis. Lipid peroxidation is... -
Interaction between the bioactive lipopeptide fengycin and lipid membranes
One class of bioactive lipopeptides produced by Bacillus subtilis, fengycin, has strong surfaceactivity and interesting antifungal property with low hemolytic activityTo gain... -
Defects in the Core Oligosaccharide in Gram Negative Bacterial Outer Membrane...
The outer membrane of Gram negative bacterial is an effective barrier for many harmful agents. We have been developing and testing advanced models of the Gram negative bacterial... -
Designing a model of the epithelial apical plasma membrane to facilitate stud...
This beam time application aims to provide preliminary data to support a wider research programme and grant application that will seek to develop a sophisticated and effective... -
Optimisation of Experimental Conditions for the Study of Anionic Self-Assembl...
We have developed a Self-assembled floating supported membrane sample system comprised of unsaturated phospholipid bilayers held ~1nm from a PEGylated charged alkane thiol SAM... -
Microdomains in model membranes using contrast variation SANS
In the present proposal small angle neutron scattering will be used in combination with contrast variation as a non-invasive method to detect the presence and size formation of... -
Free Floating Higher Plant Membrane Mimetics
We have engaged in a long term effort to build accurate bio-mimetic systems for complex structural biology studies. Recently, we have found that thiolalkylamidealcohol... -
Oxidative stress and lipid membrane disruption in bilayers containing polyuns...
Oxidation of lipid membranes is widely known to play a crucial role in many cellular processes and pathological conditions such as apoptosis, inflammation, infection, or sepsis,... -
Interfacial conformation of antibody and antigen binding capacity
Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element... -
Protein secretion: Studying the folding and assembly of membrane proteins usi...
This dataset has no description
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Understanding Surfactant-Semiconducting Polymer Interactions for Optimisation...
This dataset has no description
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Smart dendrimersomes for biosensing and triggered delivery
Dendrimersomes are an exciting new class of vesicles, comprising bilayers of dendrimer molecules that can be engineered to have sensitivity to e.g. changes in pH and enzymes.... -
Analysis of the Self-Assembled S-layer Protein SpbA on Silanised Planar Silic...
This dataset has no description
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Investigating liposome sensitivity towards phospholipases for applications in...
Liposomes are lipid-based, water-filled vesicles with wide-ranging applications in diagnostics and drug delivery. Phospholipases (PLs) are enzymes that cleave specific bonds in... -
NR characterization of aquaporin-containing silica-reinforced supported PC bi...
Despite the abundancy of sea water there are 663 million people that lack access to safe drinking water. This is due to excessive energy consumption and hence cost coupled to... -
The effect of dendrimer surface functionalization on the interaction with mod...
Dendrimers are a unique class of nano-structured vehicles for drug and gene delivery into intracellular targets. Their surface chemistry influences their transport across... -
Effect of membrane fluidity for novel dendrimer drug interaction and uptake m...
Bacteria growing resistant to common antibiotics is a growing problem and research in new types of medicines which do not induce resistance is therefore very important. Novel... -
Quasi elastic Neutron Scattering Study on Photoresponsive Cell Membranes
The integration of light sensitive materials in biotargets can allow the use of light as precise tool to control their bioactivity. Azobenzenes is largely used for these tasks,... -
Swelling of Single Supported Bilayers ¿ First Systematic Investigation of the...
This proposal addresses bilayer swelling experiements on floating supported bilayers (FSBs) in the presence of biological buffers. Previous work on multilamellar vesicles has...
