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The membrane lipid composition regulates the orientation of Tissue Factor ext...
Tissue Factor (TF) is a membrane protein located on the cell surfaces of extravascular cells. TF activity is fundamental for normal homeostasis- the physiological process which... -
Elucidating molecular mechanism of membrane disruption by designed α-hel...
We have previously shown that peptides such as G(IIKK)4I-NH2 (G4) can kill bacteria and inhibit cancer cell growth whilst remaining benign to mammalian host cells. We have also... -
Composition of model binary surfactant mixtures at the solid/liquid interface
The adsorption at the silica water (both hydrophilic) interface of anionics can be induced by the addition of non ionics, the degree of which provides information on the surface... -
calcite oil interface
The interface of CaCO3 (calcite) and oil is of paramount importance in a number of key academic and industrial areas, not least oil recovery. Neutron reflection has proved to be... -
Neutron reflection study of spin coat grapheme oxide films
We have recently been able to form a thin graphene oxide (GO) film with uniform thickness around 30±2Å from aqueous GO suspensions by spin coating (onto small wafers for... -
Assembling Biomimetic layers on monolayers of Gold Nanoparticles
Gold provides a high quality surface on which to arrange biomolecules such as proteins since we can use cysteine amino acids to deliver gold thiol chemical bonds which can... -
Adsorption maxima at the solid/liquid interface
Adsorption maxima have been reported for adsorption at the hydrophilic solid/water interface based on measurements on powders and solution analysis. Many would claim that this... -
Interaction of polypeptide with surfactant on the surface of water
This proposal constitutes part of our ongoing study towards understanding the adsorption of collagen based polypeptide and its interaction with ionic surfactants at the... -
Interfacial conformation of antibody and antigen binding capacity
Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element... -
Model anionic/non ionic surfactant adsoption at the interface below room temp...
An experiment performed on INTER last year found extreme non ideal mixing between C12E8/SLES3 at the air water interface: this feature became more extreme as the temperature... -
Magnetic Proximity Effects in Ferromagnetic-Superconducting Spin Valves
The recent experimental verification of the unique odd-frequency spin triplet superconductivity in artificial thin film ferromagnetic-superconducting structures is likely to... -
Structural characterisation of an electron-transfer protein, cytochrome c, on...
This proposal concerns the adsorption behaviour of an electron-transfer protein, cytochrome c, on modified electrode surfaces. Cytochrome c plays an important role in... -
Interfacial layer structure of peptide surfactants: the effect of hydrophobic...
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly to lead to interfacial adsorption and solution nano-aggregation.... -
Head Group charging and anaesthetic Interaction with Model Bilayers
The mechanism of general anaesthetic action is poorly understood despite their widespread use. It is hoped that investigating the interaction of anaesthetics with lipid bilayers... -
Effect of Concentration Charge and Ionic Strength on Adsorption of Small Part...
Despite the wide practical interest in particulate colloids there have been few studies that exploit the advantages of reflection and neutron scattering to study adsorption of... -
INTERACTIONS OF PAMAM DENDRIMERS WITH DESIGNER BIOSURFACTANTS AT THE SOLID/LI...
Poly(amidoamine) (PAMAM) dendrimers have been identified as potential gene vectors. We have studied their association with surfactants, dilauroylphospholiponucleosides (DLPN),... -
Charged nanogels and their ability to penetrate model lipid membranes
Drug delivery through the skin is an important route for administration of therapeutic agents. However, the outermost layer of the skin, the stratum corneum provides a... -
Stabilization of anisotropic pigment particles: Reflectivity
We wish to determine the effect of various stabilisers on anisotropic pigment particles that are being developed for use in liquid crystal composites. We will investigate the... -
The Interaction of wild-type and mutant Puroindoline B with Model Bacterial M...
Bacterial and fungal infections of cereal crops pose a considerable risk to global food security. Typically plant pathogens are controlled through the use of chemical agents... -
Layered Structure of Doped Organic Films for OLEDs
Conjugated organic semiconductors form an exciting class of materials that can be used in a variety of cutting edge technologies including organic light-emitting diodes (OLEDs),...