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Nature of the protein corona on nanoparticle surfaces
When nanoparticles enter a biosytem they rapidly acquire a protein corona. The nature of the outer part of this corona will determine the response of the biosystem to the... -
Effect of calcium ions and ionic strength on model bilayer structure
Calcium ions have been shown in a preliminary experiment to have a dramatic effect on the thickness and structure of free supported bilayer films. In this proposal we... -
Structure of Colloidal Crystals Near a Solid Surface
The structure of colloidal crystals (dispersions of particles that spontaneously order in a regular array) is known to be influenced by solid boundaries. However there are few... -
Kinetics and growth mode of aggregation phenomena inside polymer brushes
We will use time-resolved specular neutron reflectivity measurements to follow the in-situ growth of polymer brushes by surface-initiated ATRP. This will enable us to determine... -
The effect of fatty acids on the adsorption of HSA at the silica water interface
The primary biological function of albumins is to be fatty acid carriers. The complexation of fatty acids to the albumin is expected to have a strong effect on its adsorption... -
Pd, Ni, V, Nb and Ti capping layer clamping effects in hydrogen cycling in Ca...
We ask for 8 days of beam time on CRISP to study the absorption and desorption of hydrogen and deuterium in Ti/Mg/Pd trilayer samples. Our specific objective is to understand in... -
Understanding the true biological function of Plant Non Specific Lipid Transf...
Non specific lipid transfer proteins are a family of basic, cysteine rich proteins found in a wide range of plant species. The biotechnological role of these proteins in beer... -
Dynamic Adsorption of the Fusion Protein HSA-NEP at the Silica-Water Interface
HSA-NEP is a fusion protein with potential uses in treating Alzheimers disease. It consists of Neprilysin, a peptide degrading enzyme, linked to HSA, the most common protein in... -
Galvanostatic Dissolution of Multilayer Metal Systems in DES Studed using Eve...
Here we propose a study that will contribute to the final challenges of PhD training programme (Emma Palin). We will study the electrochemical dissolution of a bi-metallic films... -
The influence of transmembrane potential on the orientation of antimicrobial ...
Natural antimicrobials are of great interest, since they are antibiotics that act on the biological membrane, and it is believed that this makes it far more difficult for... -
Structure of oxidised phospholipid bilayers
Biological membranes protect cells and are essential for their survival and damaged membranes may cause serious harm to the cell. A primary cause of damage to membranes is... -
Probing the electroactive interface of ionic liquids and their solutions
We propose a detailed study of the interfacial structuring of a non-halogenated, and tribologically relevant, ionic liquid (IL) at an electrified interface, as a function of... -
Conformational analysis of subtilin / lipid II binary antibiotic/target membr...
Antibiotic resistance is pathogenic bacteria is a major clinical problem. Resistance to all antibiotiotic classes, currentl yin clinical use, has been reported. By contrast, the... -
Determination of interfacial dead layers and magnetic uniformity in half-meta...
Co-based Heusler alloys are predicted to be an ideal material for spintronics due to their high Curie temperature and potential in magnetic heterostructrue devices. We have... -
The Kinetics of Self-Exchange of a Protein at Solid/Liquid interfaces
The formation of a protein corona occurs on all surfaces exposed to biological systems and understanding of how this corona forms is vital for many aspects of medicine and for... -
Kinetics of Protein Adsorption on well-characterised polymer brushes
We wish to develop a rational understanding of the mechanisms underlying the way water soluble polymer brushes - in particular those of polyethylene oxide/polyethylene glycol -... -
An investigation on the adsorption of reverse pluronic and additives on metal...
PPO-PEO-PPO copolymer-based lubricant with extreme pressure or friction modifier additives has been introduced as boundary lubricant in metal forming. The Pluronic reverse... -
Evidence for a Diffuse Interfacial Region at the Dichloroethane/Water Interface
The 1,2- dichloroethane (DCE)/water interface is important because of its suitability as an electrochemical interface between two immiscible electrolyte soloutions. An issue of... -
Structural characterisation of vaccine-adjuvant interactions using neutron re...
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Competitive and cooperative adsorption of lysozyme and human serum albumin
All solid surfaces in contact with biological systems form a protein corona and the nature of this corona determines the further response of the biosystem to that solid surface...
