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Neutron reflectivity studies of the interaction of amphotericin with model ce...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin (AmB) has created a demand for novel anti-fungal agents that can circumvent the pathogens¿... -
Conformational changes on interaction of cytochrome c with lipid monolayers.
The main objective of the present work is to gain an understanding of the interaction of the cationic protein, cyt c with anionic lipid membranes. This objective will be... -
The effect of anionic lipid unsaturation on the interaction with cytochrome c
While peripheral membrane protein-lipid interactions were originally considered to be solely electrostatic in nature, it is now accepted that they encompass more complicated,... -
Molecular interactions between phospholipid monolayers and dimethylsulphoxide
Neutron reflectivity will be employed to investigate the interaction between dimethylsulphoxide and monomolecular films of phosphatidylcholine. The monolayer will be used as a... -
Investigation of phase diagrams of polysaccharides
This project concerns fundamental and strategically important research underlying the development of new drug delivery vehicles. We propose to sample phase diagram of... -
Superconductivity induced changes in the ferromangetic order of Y(1-x)PrxBa2C...
By polarized neutron reflectometry we want to investigate the magnetic field profile in Y(1-x)PrxBa2Cu3O7/La(2/3)Ca(1/3)MnO3 high-Tc superconductor/ferromagnet superlattices. In... -
Electrostatic interaction effects in orientationally disordered phases
Plastic phases are characterized by a positional ordering of the molecular centers of mass while molecules are rotating in a hindered way. Therefore these phases are... -
Solvation and interaction of polymers showing lower critical solution tempera...
LCST, or ¿cloud point¿ is a property of some types of polymers in solution. At low temperatures, the polymers are fully solvated and exist as extended conformations in solution.... -
Calcium mediated interaction between siRNA and phospholipid bilayers: the eff...
The main objective of the present study is to gain an understanding of the nature of the interaction of ¿phospholipid membranes¿ with small, interfering RNA (siRNA) in the... -
Kinetics of amphotericin B interaction with model human and fungal cell membr...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents. The successful development of... -
Switchable adhesion between oppositely charged polyelectrolytes: dependence o...
Tuning the interactions between different surfaces has technological benefits in areas such as adhesion, compatibilisation and nano-actuators. We shall study the interaction... -
Effect of membrane fluidity for novel dendrimer drug interaction and uptake m...
Bacteria growing resistant to common antibiotics is a growing problem and research in new types of medicines which do not induce resistance is therefore very important. Novel... -
Investigation of the core-shell interaction in stabilised PdAu nanoparticle c...
Bimetallic nanoparticles are attractive materials due to their novel electronic, magnetic optical and catalytic properties which are distinctly different from those of their... -
Off-specular reflectivity from conjugated polymer heterojunctions
Using conjugated polymers as the active materials in electronic and optoelectronic devices opens up the possibility of fabricating all-polymer devices, such as active matrix... -
The interaction of Plant Defensins with Model Lipid Membranes : Understanding...
Plants do not have the sophisticated immunoglobulin immune systems of vertibrates, instead they posses a series of stimuli based responses which defend against pathogentic... -
Hydrogen storage: interaction between hydrogen and lithium nitride at high pr...
We apply for beam time on TOSCA to investigate this highly unusual system. Lithium nitride appears unique among storage materials in its ability to take up significant amounts... -
SANS studies of mixed phospholipid:sterol vesicles and their interaction with...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
The calcuim mediation interaction of DNA with monolayers of DSPC and DOPE
The main objective of the present work is to complete some work aimed at gaining an understanding of the interaction of phospholipid membranes containing the neutral helper... -
The hydrophobic interaction A peptides and a lipid monolayer at the o...
This proposal relates to the study on the fundamental level, the hydrophobic interaction A peptides and a lipid monolayer at the oil-water interface. NR will be used to... -
Study of the interaction of thermoresponsive naogels with lipids
This proposal seeks to characterise the hydrophobic interaction of thermoresponsive nanogels designed for drug delivery through the skin with a lipid monolayer as a function of...
