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Folated derivatized nanoemulsions for the treatment of cancer
Nanoemulsions (NE) i.e. nanoparticles containing a fluid lipid or oil dispersed in water and stabilized by a surfactant particles have attracted considerable attention as... -
Structure of Cellulose Nanofibril Gels with Alcohols
Our group has been working partially oxidized cellulose nanofibrils which form gels in aqueous formulations. Recently we have observed that these fibrils also gel when dialysed... -
AOT stabilized aqueous ferrofluids
The aim of the experiment is to employ SANS to study the physical properties of a novel and very stable aqueous Fe3O4 ferrofluid system stabilized by the commercially available... -
Solution aggregation of short peptide amphiphiles
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly to lead to interfacial adsorption and solution nano-aggregation.... -
Contrast Variation Experiments for Probing the Structure of Pickering Nanoemu...
Polymerisation-induced self-assembly is an efficient and versatile method of producing functional block copolymer spheres, worms and vesicles in a range of media (e.g. water,... -
Nanosuspsomicroemulsions: nanosuspension stabilty
At Kings College London we have recently developed a novel combination formulation, a nanosuspsomicroemulsion (NSME), comprising of a microemulsion (ME) containing one drug and... -
Temperature and flow stability of model sodium alkylbenzene sulfonate (NaLAS)...
Linear sodium alkylbenzene sulfonate (NaLAS) is one of the most extensively used anionic surfactant in the world, mainly as a biodegradable laundry detergent, with an annual... -
Structural origin of anomalous relaxation behaviour in alcohol-water mixtures
In recent dielectric and calorimetric studies of some alcohol-water mixtures we have discovered unexpected and unexplained relaxation behaviours. Our aim with this proposal is... -
The effect of alcohol chain length on the interaction between PS-PEO copolyme...
In many applications, surfactants are formulated with a variety of additives to achieve a desired range of properties; polymers and cosurfactants/cosolvents (such as alcohols)... -
Resolving mixing.demixing effects in hydrocarbon/fluorocarbon micelles
Surfactants ability to lower surface tension and act as solubilising agents is critical for their wide use in everyday products. An oily hydrocarbon (HC) "tail group" attached... -
Exchange kinetics of complex coacervates core micelles
Coacervates have been studied for a long time for their unusual properties: they are dense networks of charged polymers that are soluble in water. Instead of flocculating when... -
Cucurbituril HostGuest Micellar Systems: Structure and Self-Assembly
One of the grand challenges in the physical sciences is fabricating materials with a defect-free controlled structure on the submicron scale. Realisation of this challenge will... -
Structure of Cellulose Nanofibril Gels
This proposal is part of a new project based on understanding the formation of gels in suspensions of partially oxidised cellulose nanofibrils with small amounts of salt or... -
SANS studies of phospholipid:sterol vesicles and the membrane interactions of...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
The solution structure of E.coli peripheral membrane protein FtsA solubilised...
We will measure the solution structure of a protein complex from bacteria essential for cell division. The two proteins, FtsA and FtsZ, are known to interact with each other... -
Small angle neutron scattering study on the interaction between antimicrobial...
Bacterial endotoxins, or lipopolysaccharide (LPS), released from the gram negative bacterial membrane, form different aggregates in solution which morphology depends on the type... -
Small-Angle Neutron Scattering studies of a bacterial colonization factor
We plan to carry out SANS experiments on a bacterial colonization factor to elucidate how it interacts with chitin, which is found on the surface of plankton and crustaceans.... -
Effect of pH on the shape of oil-in-water microemulsions formed by a zwitteri...
Despite interest in microemulsions as drug delivery vehicles, there is a lack of structural understanding to justify the formulations used. The present study examines the use of... -
Effect of surfactant head group on micelle structure of drug containing micelles
The aim of the current project is to probe (at the nanometer length scale) the relationship between the solution structures of a surfactant molecule, the aggregate(s) it forms... -
Surfactant induced gelation of TEMPO-oxidized cellulose; Using betaine-based ...
Our group has been working cellulose nanofibrils (OCNF) which form hydrogels in the presence of certain additives. Previously, we have studied the effect of salt, single...