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Interaction of a pH-sensitive Polymer with a Model Lipid Membrane in the Form...
This SANS experiment was proposed by 4 PhD students from 3 different institutions in a Marie-Curie Training Network. They are all in the second year of their PhD and their... -
SANS contrast measurements on important protein/DNA interactions from RCaH
This proposal is to perform SANS contrast measurements on three protein/DNA interactions currently worked on at the Research Complex at Harwell. This is part of an ongoing... -
Mixed micelles of nonionic and metallosurfactants (P123/CTAF) as porogens of ...
Non-ionic/metallosurfactant (P123/CTAF) mixed micelles are used as templates for the hydrothermal synthesis of mesoporous ferrisilicate materials. It was hypothesized that... -
Micellization in mixtures of surfactants used in fire-fighting foams
The aim is to probe the mixed micellar compositions of three common industrial fluorotelomer surfactants used in fire-fighting foam formulations (Figure 1) using contrast... -
SANS evaluation of novel nanocolloidal drug carriers
With the beamtime requested we plan to employ small-angle neutron scattering (SANS) to study novel nanocolloidal drug carriers prepared using lipids, surfactants and... -
The effect of particles on the structure of mucin ¿understanding the challeng...
Progress in the development of nano-sized hybrid therapeutics and nano-sized drug delivery systems - "nanomedicines" - over the last decade has been remarkable. One key... -
A new approach to viscosity enhancement of oils and CO2
Due to the naturally low viscosity of liquid CO2 (0.1-1.0 cP pressure/temperature dependent) the CO2 is prone to ¿fingering¿, limiting the efficiency of CO2-EOR [1]. In order to... -
Peptide resistance in asymmetric MRSA-mimetic vesicles
We have been investigating the influcence of the cationic staphylococcal lipid lysyl-phosphatidylglycerol (L-PG) on bacterial resistance to antimicrobial peptides (AMPs). Using... -
Effect of shear and charged polymers on cellulose microfibrils
Cellulose is an important natural material used in many industrial applications, such as food and medicine. Cellulose micro-fibrils (CMF) are produced from wood, plants, and... -
SANS studies of mixed phsopholipid:sterol vesicles and their interaction with...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
On the structure and composition of non-lamellar lipid-based liquid crystalli...
Liquid crystalline particles consisting of glycerol dioleate (GDO) / soy phosphatidylcholine (SPC) mixture and stabilised by polysorbate 80 (P80) have proven to be suitable as... -
Contrast matching of selectively deuterated glycerides for scattering studies...
Lipid nanoparticles (LNPs) can be formed from glycerides and loaded with diverse cargo for healthcare applications. A key advantage of LNPs over liposomes is the significant... -
Unlocking Structure-Property Relationships in Composite Semiconducting Nanopa...
Colloidal dispersions of organic semiconducting nanoparticles (NPs) have shown promise for the generation of active layers in organic solar cells.Composite NPs containing a... -
Aggregation in ionic liquids
The aim of this experiment is to investigate surfactant aggregation in ionic liquids and also ionic liquid ¿ oil and ionic liquid ¿ water microemulsions via SANS. Contrast... -
Solution Aggregation of Short Peptide Amphiphiles
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly, leading interfacial adsorption and solution nano-aggregation.... -
Surfactant-Controlled Assembly of Amphiphilic Diblock Polythiophenes
Conjugated polythiophenes (PTs) have emerged as a promising class of material in organic solar cells. The device performance depends on the inherently-linked optoelectronic... -
Investigation of the solution structure and pore dynamics of Bacillus anthrac...
Understanding the nature of protein translocating events through bacterial pores offers an uniqueopportunity to develop novel drug delivery systems, whilst also providing... -
Probing the internal structure of ethyl butyrate containing microemulsions us...
The proposal aims to establish the location of the oil, ethyl butyrate in dodecyldimethylamine-N-oxide (DDAO) microemulsions. Molecular dynamic simulations have proposed that a... -
Fire-fighting surfactants: aggregation and micellar composition
The aim is to probe micellar structures of three common industrial fluorotelomer surfactants used in fire-fighting foam formulations (Figure 1) using contrast variation SANS.... -
Contrast variation SANS to understand drug directed assembly of multi lamella...
Recurring infection following dental interventions such as fillings is the most common reason for failure, leading to further treatments including root canal therapy, where the...
