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Mechanism and rates of phospholipid exchange and flip-flop under physiologica...
Variation in lipid composition between different biological membrane and across membranes are vital for a wide range of cellular functions. Significant differences in lipid... -
Biological small-angle neutron scattering on Zoom
This dataset has no description
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Understanding the microstructure of polymer blends used as control release co...
Solid oral dosage forms consist of polymer layer encapsulated drug-bound particles with a desired drug release profile e.g. pulsatile, controlled, delayed and targeted,... -
Unravelling the thermal denaturation and stability of the solution structures...
The glycosylation of glycoproteins is a major determinant of their stability, and glycans also affect their aggregatibility (precipitation). An understanding of this is... -
Exchange kinetics of complex coacervates core micelles
Coacervates have been studied for a long time for their unusual properties: they are dense networks of charged polymers that are soluble in water. Instead of flocculating when... -
Effect of End Group on RAFT-Polymers for Lipid Nanodisc Stabilisation
Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Previously we studied discs formed using... -
SANS Investigation into the Mode of Interaction between Antibiotics and Diffe...
In this part of proposed work, we wish to explore how antibiotics minocycline and tetracycline interact with model lipid bilayers in the form of SUVs, mimicking key features of... -
Effect of oxidation on lipid raft formation: a SANS study
The separation of particular lipids in cell membranes into liquid ordered and liquid disorder regions is thought to have a major influence of the functioning of membrane... -
Controlling diblock co-polymer morphologies via selective solvent annealing
Diblock co-polymers consist of two polymer chains with different chemical properties tied together at a central linking block. The interactions between the two blocks result in... -
The formation of elongated aggregates in supercritical CO2 through the mixing...
This proposal involves manipulating the curvature of aggregated polar materials in supercritical CO2 (scCO2) by tuning the mixing ratio of fluorocarbon (FC) and hydrocarbon (HC)... -
Combined SAXS and SANS analysis of strained composite materials
The microscopic origins of strain softening (Payne Effect) are vital to our understanding of energy dissipation in vehicle tyres. This proposal builds on our recent SANS... -
Structural stability of novel anticancer hexameric fusion protein: SANS inves...
A shift towards antibody-based cancer treatments has occurred due to their ability to provide targeted cancer treatment with fewer negative side effects than traditional... -
SANS investigation of proteins trapped in hydrogels formed by binary mixtures...
Aqueous solutions of guanosine 5-monophosphate (GMP) can turn into isotropic gels by the addition of guanine (Gua). The Gua:GMP hydrogel property of including a significant... -
Interactions of Cationic Surfactants with Phospholipid Vesicles: Influence of...
Surfactants are frequently used in personal care products to improve the wetting and oil solubilizing qualities of the products, which also leads to the skin irritation by... -
Dynamics of amyloid protein fibril elongation using isotope-labelled SANS
This proposal combines optical spectroscopy with neutron scattering using novel labelling strategies to investigate ?amyloid? protein fibrils. Variations in packing and in the... -
The formation of elongated aggregates in supercritical CO2 through the mixing...
This proposal involves manipulating the curvature of aggregated polar materials in supercritical CO2 (scCO2) by tuning the mixing ratio of fluorocarbon (FC) and hydrocarbon (HC)... -
Probing the interactions of aqueous hydrophobically-modified microgel particl...
A recent LOQ experiment revealed that co-monomers are homogenously distributed within regions of colloidal poly(NIPAM) microgel particles. This proposal has two aims: (1) refine... -
Novel gels with supercritical carbon dioxide
This proposal is to probe the gel structure with High Pressure SANS (HP-SANS) using an in-line pressure cell. The ability to control the properties of supercritical CO2,... -
Biomolecular Cryoprotection in Deep Eutectic Solvents
Protecting biomolecules, such as proteins and enzymes, from the effects of cooling and freezing is important for the storage and handling of pharmaceuticals. Deep eutectic... -
Elucidating the unique role of non-standard collagen helices in forming key p...
The collagens are the most abundant proteins in mammalian systems, comprising up to 25% of human proteins. Their three-stranded triple helix structures are a major determinant...
