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Understanding the antimicrobial activity of the salivary protein Histatin 5
The goal of this project is to understand the antimicrobial activity of the intrinsically disordered salivary protein Histatin 5, which acts in defence against oral candidiasis... -
Effects of external and chemical pressure on the magnetovolume effects in Ba3...
Ba3BiIr2O9 and Ba3BiRu2O9 undergo very unusual structural transitions at 74 and 176 K respectively, with instantaneous negative thermal expansion of up to 1% in the Ir compound.... -
3He insert commissioning
This dataset has no description
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Centrifugal Force Spun Fibres
Centrifugal force spinning is a technique that has recently come into light as an easy route to producing large quantities of nano- to micro- scale polymer fibres in a short... -
A SANS Study on the Influence of Shear on Peptide Fibrillisation
Time-resolved SANS will be performed to investigate the effect of shear on the fibrillisation of insulin following denaturation. The rheological response will be measured... -
The structure of clay swelling inhibitors TMA and TEA under oil-field conditions
Shale swelling is particularly problematic in the oil and gas exploration sector, as environmentally friendly water based muds are invariably used during drilling operations to... -
Rosseinsky programme access GEM
The proposal develops recent observations on spin-lattice coupling in incommensurate materials (objective - measure influence of applied field on evolution of structural... -
Reversible ammonia storage; Structure and stoichiometry of defect imide-amide...
In this proposal we will study the average and local structure changes in Li-N-D imide-amides formed as intermediates during the ammoniation of Li3N and deammoniation of LiND2.... -
Surface adsorption in hydrophobin, Tween and β-Casein mixtures
Increased environmental pressures and awareness is promoting a major drive towards an increased use of biosurfactants to produce more biosustainable and biodegradable consumer... -
The impact of polyelectrolytes on surfactant adsorption onto cellulose surfaces
Studying surfactant and mixed surfactant adsorption on model solid surfaces, which mimic real surfaces such as fabrics, hair and skin, is starting to provide a real insight into... -
µSR studies of the superconducting and magnetic properties of FeSe1-xSx
FeSe1-xSx is an important model system for investigating the relationship between superconductivity and nematicity. The nematicity can be suppressed systematically by the... -
Investigation of the surface structure of anionic surfactants induced by the ...
This proposal is part of a major EPSRC (EP/GR065705) / Unilever funded programme to develop and control the spontaneous formation of surfactant multilayer structures at... -
Antibiotic Interactions with models of the Gram negative bacterial outer memb...
Gram-negative bacteria, which cause a variety of diseases including meningitis, plague, sepsis and food poisoning, are becoming increasingly antibiotic resistant. One reason is... -
NR study of binding of short antimicrobial alpha-helix peptides with model li...
In this work we explore how our rationally designed peptide amphiphiles bind onto lipid monolayers using neutron reflection combined with deuterium labelling to the lipids,... -
Co-adsorption of monoclonal antibodies and non-ionic surfactants at the air/l...
Nonionic surfactants usually do not show affinity to proteins and they work via competitive surface and interfacial processes in a binary mixture with protein. However, we show... -
Neutron reflectivity studies of the interaction of amphotericin with model ce...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin (AmB) has created a demand for novel anti-fungal agents that can circumvent the pathogens¿... -
Effect of intergranular stress on creep deformation in 316H during high tempe...
Creep lifetime of high temperature power plant materials are significantly affected due to predicted and unpredicted cyclic loading during plant operation. Our previous study... -
Oxidation of gram-negative cell-wall proxy with OH radicals - kinetics and me...
Hydroxyl radicals may be used as disinfection agent in the advanced oxidation processes or tertiary treatment of waste and occasionally drinking water. In this exploratory work,... -
Insertion of antimicrobial peptides into phospholipid monolayers at air/liqui...
We have designed a series of cationic peptides with different helix repeats that can kill bacteria but remain benign to mammalian host cells. The selectivity to cell types is... -
Determination of the detection limits and quantitative analysis reliability o...
Neutron diffraction offers one of the most interesting and meaningful methods for non destructive quantitative determination of the phase composition of materials. However, it...
