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On the structure and composition of non-lamellar lipid-based liquid crystalli...
Liquid crystalline particles consisting of glycerol dioleate (GDO) / soy phosphatidylcholine (SPC) mixture and stabilised by polysorbate 80 (P80) have proven to be suitable as... -
Temperature-dependent structural behaviour of the collapse transition of high...
We shall use small angle neutron scattering to investigate the structural behaviour of the temperature sensitive highly branched poly(N-isopropyl acrylamide) [PNIPAM]. These... -
SANS studies of mixed phsopholipid:sterol vesicles and their interaction with...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
Exploring CO2-philic/ CO2-phobic amphiphiles, cross-linkers and HC-polymers f...
Over the last two decades, many polymers have been tested to increase CO2 viscosity for applications in enhanced oil recovery using CO2 (CO2-EOR). Unfortunately, conventional... -
The mode of action of a novel disruptive antimicrobial technology on model me...
A Unilever proprietary technology has been shown to inhibit biofilm growth and development, and is also found to possess antimicrobial activity, effective both as a... -
Responsive polymer brushes grafted from gold nanoparticles: interaction with ...
We will use SANS to characterize dispersions of gold nanoparticles functionalized with poly(dimethyl aminoethyl methacrylate) brushes grafted from 25 nm gold nanoparticle... -
A new approach to viscosity enhancement of oils and CO2
Due to the naturally low viscosity of liquid CO2 (0.1-1.0 cP pressure/temperature dependent) the CO2 is prone to ¿fingering¿, limiting the efficiency of CO2-EOR [1]. In order to... -
The effect of particles on the structure of mucin ¿understanding the challeng...
Progress in the development of nano-sized hybrid therapeutics and nano-sized drug delivery systems - "nanomedicines" - over the last decade has been remarkable. One key... -
SANS evaluation of novel nanocolloidal drug carriers
With the beamtime requested we plan to employ small-angle neutron scattering (SANS) to study novel nanocolloidal drug carriers prepared using lipids, surfactants and... -
Temperature driven self-assembly of amphiphilic block copolymers in water.
Amphiphilic copolymers with perfluoroalkyl blocks provide self-assembled nanostructures, in water, via the association and/or self-folding of the copolymer chains. This feature... -
Conformational behaviour of amphiphilic polymethacrylate-poly(acrylic acid) c...
We shall use SANS to investigate the conformational behaviour of a range of amphiphilic copolymers with varying architectures: graft, hyperbranched block, hyperbranched random,... -
A SANS Study on the Influence of Shear on Peptide Fibrillisation
Time-resolved SANS will be performed to investigate the effect of shear on the fibrillisation of insulin following denaturation. The rheological response will be measured... -
Centrifugal Force Spun Fibres
Centrifugal force spinning is a technique that has recently come into light as an easy route to producing large quantities of nano- to micro- scale polymer fibres in a short... -
Polymer layer structure in stabilised metal nanoparticles for heterogenous ca...
The controlled synthesis of precious metal nanoparticles of the appriopriate chemical composition, optimised size and morphology for use in catalysis is an ongoing experimental... -
Controlled Assembly of Cationic Polythiophene-Surfactant Complexes
We intend to study the phase behaviour of 2 cationic polythiophenes, P3MAHT and P3ImiHT, in the presence of the perfluorinated surfactant potassium... -
Encapsulation of hydrophobic species in mixed micelles in polymer solutions
This proposal continues our investigations into film-forming polyelectrolyte-surfactant solutions. We have found that mixed micelle systems offer greater control over micelle... -
CATIONIC POLYMERS AS POTENTIAL GENE DELIVERY AGENTS: EVALUATION OF CONFORMATI...
Bio-responsive polymers hold great promise as delivery vehicles for drugs, peptides and proteins as their chemistry can be tuned to effect a change in physico-chemical... -
W/CO2 nanodispersions as an energy-saving nanoreactor separable by pressure a...
Recent studies implied an unusual headgroup (HG)-free, fluorocarbon (FC) surfactant Nohead FC6-HC4 to form stable, W/CO2 nanodispersions (W/C NDs). With the unusual surfactant... -
Aggregation of new silicon containing surfactants (NOT silicone surfactants)
The results from this experiment will develop alternatives to controlling surface tension through the design of 21st century surfactants (better performance at lower... -
Reversible folding-unfolding and structural study in protein-ionic liquid sys...
It has been recently shown that reversible thermal folding-unfolding, stabilization and high solubility of proteins (e.g. lysozyme) can be achieved when dissolved in protic...