977 datasets found

Atherosclerosis and subsequent clinical complication is one of the biggest killers in the western world, with a death toll reaching 16.7 million deaths per year. Although many...

Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Previously we studied discs formed using...

The understanding of the plant wax-surfactant interaction process is crucial to the development of more effective pesticide and fungicide formulations, essential for improving...

Cytochrome P450s are ubiquitous hemeprotein monooxygenases that catalyse numerous biochemical reactions, and the investigation on them is of significance to both the protein...

Lipoproteins are the main carriers of lipids in the body. HDL is believed to favor cholesterol removal and decrease the risk to develop atherosclerosis and related...

Atopic dermatitis (AD) is a chronic inflammatory skin condition affecting up to 20% of children and 3% of adults, resulting in significant reduction in quality of life and costs...

When we confine water in extremely small spaces it starts to move extremely slowly. This behaviour is critical to helping biological molecules like proteins function normally....

The proteins of the outer membrane of Gram-negative bacteria are critical for bacterial survival,from providing basic physiological functions, to impairing virulence and...

Novel self-assembling di-block polymers have been designed multi-component polymer-drug conjugates for the delivery of cytotoxic drugs to solid tumours. It is known that the...

Layered double hydroxides (LDHs) have recently been identified as interesting drug delivery vehicles due to their ability to intercalate guest molecules. Additionally, LDHs...

Ionogels are a new class of soft matter that have only really become subject of detailed research in the past decade. As a result, much of the contemporary literature is still...

In bacteria, mechanosensitive ion channels such as MscL protect cells against osmotic shock, but, as with all ion channels, they have the potential to act as an Achilles heel,...

A cell membrane can contain hundreds of different lipid molecules, but our understanding of the dynamics of cell membranes is very limited. As a result of a collaboration...

In the context of a project in collaboration with ISIS that focuses on structural studies under mechanical confinement, with a specific focus on biological lubricants, the...

Using an enzyme mediated conjugation method we have prepared well-designed protein-polymer conjugates using a model protein, green fluorescent protein (GFP) with...

Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Previously we studied discs formed using...

The goal of this project is to understand the antimicrobial activity of the intrinsically disordered salivary protein Histatin 5, which acts in defence against oral candidiasis...

The process of cell division requires precise duplication of the genetic material. The separation of the two strands of DNA and the progression of the replisome are driven by...

Nano-diamond particles are synthesised by detonation of TNT and Hexogen, resulting in a shockwave which produces diamond nanoparticles with an average size of around 5 nm,...

Cholesterol levels in membranes of cellular organelles varies immensely. For example, cholesterol in the plasma membrane (PM) is 35¿45% of the lipid content , while in the...