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Folated derivatized nanoemulsions for the treatment of cancer
Nanoemulsions (NE) i.e. nanoparticles containing a fluid lipid or oil dispersed in water and stabilized by a surfactant particles have attracted considerable attention as... -
SANS studies of Physiogel creams
Aqueous creams are widely used to treat skin conditions like rosacea, dermatitis and psoriasis.They are very complex chemical mixtures, and our knowledge of their molecular... -
Effect of drug structure on solubilisation in a range of surfactant micelles
The aim of the current project is to probe (at the nanometer length scale) the relationship between the structure of a surfactant molecule, the micelles it forms in solution,... -
Effect of temperature on raft formation
Neutron reflectivity in combination with contrast variation will be used to determine the changes in composition of monolayers of either dipalmitoylphosphatidylcholine:... -
Effect of polar solvent on the formation of reverse phospholipid microemulsions
It is the aim of the proposal is to perform small angle neutron scattering (SANS) studies combined with contrast variation to determine the size and structure of the... -
Effect of oxidation on lipid raft formation: a SANS study
The separation of particular lipids in cell membranes into liquid ordered and liquid disorder regions is thought to have a major influence of the functioning of membrane... -
Effect of drug on the micelles formed by ionic surfactants
The aim of the study is to use SANS in combination with contrast variation to determine the effect of solubilising the lipophilic drug, testosterone propionate, in micelles... -
Effect of lipid oxidation on raft formation using contrast variation SANS
The very heterogeneous, but non-random, arrangement of lipids and proteins in cell membranes are of major scientific interest and led Simons and Ikonen to propose that ¿rafts,¿... -
Effect of emulsifier and added preservative on the structure and stability of...
Investigations will be performed to determine the effect of composition on the internal structure of semi-solid oil-in-water emulsions designed to model the GlaxoSmithKline... -
The action of membrane lytic compounds on model membranes.
The study of antifungal and antibacterial action is of great interest and there are still many unknowns concerning the action of membrane lytic materials, and the way that... -
A Total Scattering Study of the Solubilising Mechanism of a Hydrotrope.
We request 5 days on NIMROD to collect total scattering data of aspirin and caffeine at pH7 and pH3 in order to determine the origin of the effect of the hydrotrope caffeine on... -
Molecular architecture of novel, trichain-containing vectors for gene delivery
We have recently developed novel ternary lipopolyplex vectors (i.e. gene delivery vectors containing cationic lipid, plasmid DNA and a cationic peptide) in which, for the first... -
Nanosuspsomicroemulsions: nanosuspension stabilty
At Kings College London we have recently developed a novel combination formulation, a nanosuspsomicroemulsion (NSME), comprising of a microemulsion (ME) containing one drug and... -
Characterisation of Hybrid Lipid-Polymer Nanoparticles
Hybrid lipid-polymer nanoparticles have demonstrated potential as drug delivery vehicles. The current proposal aims to use small angle neutron scattering (SANS) in combination...
