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Interaction of human dihydroorotate dehydrogenase with ubiquinone in model li...
Human dihydroorotate dehydrogenase (DHODH) is a membrane-bound enzyme of clinical interest and a well-validated drug target for e.g. rheumatoid arthritis and multiple sclerosis.... -
Oxidative stress and lipid membrane disruption in bilayers containing polyuns...
Oxidation of lipid membranes is widely known to play a crucial role in many cellular processes and pathological conditions such as apoptosis, inflammation, infection, or sepsis,... -
Investigating the structure of the pulmonary lung surfactant at the air-water...
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Magnetic contrast NR to resolve MscL opening under PXG challenge: influence o...
In bacteria, mechanosensitive ion channels such as MscL protect cells against osmotic shock, but, as with all ion channels, they have the potential to act as an Achilles heel,... -
Using SANS2D to resolve the opening of MscL clusters in proteoliposomes in re...
In bacteria, mechanosensitive ion channels such as MscL protect cells against osmotic shock. Although crucial for protecting cells, as with all ion channels, they have the... -
Controlling Protein Adsorption on Silicon with Trivalent Ions: Understanding ...
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Probing the electroactive interface of ionic liquids and their solutions
We propose a detailed study of the interfacial structuring of a non-halogenated, and tribologically relevant, ionic liquid (IL) at an electrified interface, as a function of... -
Comparative Interaction Studies of Antimicrobial Agents on Bacterial Membrane...
The outer membrane (OM) of Gram-Negative bacteria (GNB) is an asymmetric structure which contains complex lipids known as lipopolysaccharides (LPSs) on the outer surface. LPSs... -
flipping and desorption energetics of cholesterol in lipid-raft environments
Cholesterol levels in membranes of cellular organelles varies immensely. For example, cholesterol in the plasma membrane (PM) is 35¿45% of the lipid content , while in the... -
Calibration Cycle 15/4
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Calibration INTER
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Effect of oxidative stress on polyunsaturated lipid bilayers modulated by cho...
The exposure of biological membranes to reactive oxygen species is key for many pathological conditions, including inflammation, infection, or sepsis. Lipid peroxidation is... -
Role of apolipoprotein E variant on HDL interactions at model cell membranes
Atherosclerosis is the leading cause of death in western society, its consequences such as strokes and heart attacks arise from the build-up of plaques of fat which accumulate... -
Quantifying the Asymmetry in Cell Membrane Mimetic Supported Lipid Bilayers.
Cell membranes are characterised by complex lipid composition and asymmetric distribution of lipids (lipids facing the outside of the cell are different from the lipids that are... -
Cell-penetrating peptides interaction with model membranes
Cell-penetrating peptides (CPPs) are short cationic peptides that are efficiently taken up by cells. They are able to co-internalize therapeutic molecules into cells for... -
D2O Vapour Diffusion at the Air Water Interface
A theoretical estimate of the H/D exchange rate for an open trough (e.g. D2O in ambient atmosphere, 50% relative humidity) yields an amount of exchanged liquid of the order of... -
Liquid-Liquid interface for solvent extraction
Liquid-Liquid or solvent extraction partitioning methods have been developed to separate compounds based on their different solubilities in immiscible liquids, usually water and... -
Electrostatic Control of Protein Adsorption under Re-entrant Conditions
Protein adsorption is a process relevant in many research fields such as biology, medicine and food processing. Its mechanism is influenced by many parameters. Our group has... -
Surface charge induced layering of ionic liquids on mica
The structure of ionic liquids at charged interfaces is an exciting and vibrant area of current research. Previous surface force apparatus experiments have shown layering up to... -
Understanding the interfacial behaviour of bile salts to better engineer lipi...
The current project aims at elucidating how bile salts (BS) structure influences their interfacial behaviour and their impact on fat digestion. Neutron reflectivity (NR) is the...
