117 datasets found

Chiral gemini surfactants containing stereogenic centers and two amphiphilic moieties, not only maintain the chiral properties, but also exhibit stronger aggregation properties,...

In order to maintain their asymmetric lipid distribution, cellular membranes have a number of means to translocate lipid molecules across the bilayer. On top of the well-studied...

Antibiotic peptides are generally small, simple, usually alpha-helical peptides, which nevertheless show quite complex biological behaviour. We have been studying the gating...

In the soil environment, organic matter such as humic acid has a strong influence on the behaviour of organic pollutants such as perfluoroalkyl substances (PFASs) and their...

In this work we explore how our rationally designed peptide amphiphiles bind onto lipid monolayers using neutron reflection combined with deuterium labelling to the lipids,...

The global increase of bacterial resistance to antibiotics has led to increasing interest in research focusing on the development and characterization of new antimicrobial...

A proof-of-principle experiment to use the convenient scattering length of perfluorinated alkyl surfactants to measure partitioning to lipids at the air-water interface,...

We have previously shown that peptides such as G(IIKK)4I-NH2 (G4) can kill bacteria and inhibit cancer cell growth whilst remaining benign to mammalian host cells. We have also...

Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). The mitochondrial apoptotic pathway is a...

This SANS experiment was proposed by 4 PhD students from 3 different institutions in a Marie-Curie Training Network. They are all in the second year of their PhD and their...

Off-specular neutron reflection is potentially a powerful technique for studying the lateral organisation of phospholipid bilayers. However, this has not yet been demonstrated....

The aim of this study is to try to understand how antimicrobial peptides bind to model lipid monolayers mimicking different cell membrane types. Following our previous work,...

Marine biofouling compromises function and reliability of marine equipment, causing considerable economic and environmental damage. Biocides for fouling prevention are...

The nanodisc (ND) is a self-assembled discodial particle composed of phospolipids and two amphipathic belt proteins, termed Membrane Scaffold Proteins (MSP). This stable,...

This proposal addresses bilayer swelling experiements on floating supported bilayers (FSBs) in the presence of biological buffers. Previous work on multilamellar vesicles has...

The proposal is a continuation to collect more data for publication. The generation of chlorine radicals in the previous experiment was initially tricky and difficult. However...

Puroindolines are basic, cysteine rich proteins of ~13KDa, which have attracted significant interest due to their role in determining the endosperm texture of Wheat and seed...