Images of the type Sab spiral galaxy M81 were obtained in far-UV and near-UV bands by the Ultraviolet Imaging Telescope (UIT) during the Astro-1 Spacelab mission of 1990 December. Magnitudes in the two UV bands are determined for 52 H II regions from the catalog of Petit, Sivan, & Karachentsev (1988A&AS...74..475P). Fluxes of the H-alpha and H-beta emission lines are determined from CCD images. Extinctions for the brightest H II regions are determined from observed Balmer decrements. Fainter H II regions are assigned the average of published radio-H-alpha extinctions for several bright H II regions. The radiative transfer models of Witt, Thronson, & Capuano (1992, ApJ, 393, 611) are shown to predict a relationship between Balmer Decrement and H-alpha extinction consistent with observed line and radio fluxes for the brightest 7 H II regions and are used to estimate the UV extinction. Ratios of Lyman continuum flux (computed from the extinction corrected H-alpha flux) to the extinction corrected far-UV flux are compared with ratios predicted by model spectra computed for IMF slope equal to -1.0 and stellar masses ranging from 5 to 120 Msun. Ages and masses are estimated by comparing the H-alpha and far-UV fluxes and their ratio with the models. The total of the estimated stellar masses for the 52 H II regions is 1.4x10^5^ Msun. The star-formation rate inferred for M81 from the observed UV and H-alpha fluxes is low for a spiral galaxy at ~0.13 Msun/yr, but consistent with the low star-formation rates obtained by Kennicutt (1983ApJ...272...54K) and Caldwell et al. (1991ApJ...370..526C) for early-type spirals.