A SESANS study of the structures of bile salts-polymer complexes that facilitate the solubilisation of poorly soluble drugs

DOI

Nearly 40% new drugs are poorly water-soluble.To achieve good oral absorption of these compounds, solubilisation in the gut fluid is extremely important.Water-soluble polymers can improve the absorption of these drugs.To date there is no insight into the effect of gut bile salts on the in vivo behaviour of water-soluble polymer based oral delivery systems for poorly soluble drugs.The aim of this project is to understand the effects of the polymer-bile salts interactions on the solubilisation process of poorly water-soluble compounds using SESANS. A better understanding of the polymer-bile salt interaction through a structural characterisation of the polymer-surfactant assemblies (100-300nm) by SESANS can provide useful guidance on polymer selection,rationalising formulation development and lead to the generation of new bio-polymers designed for the effective drug delivery.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24089273
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24089273
Provenance
Creator Dr Upali Jayasooriya; Dr Sheng Qi; Dr Francesca Baldelli Bombelli; Dr Robert Dalgliesh; Miss Claudia Pigliacelli
Publisher ISIS Neutron and Muon Source
Publication Year 2015
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2012-07-11T08:15:27Z
Temporal Coverage End 2012-07-13T08:26:44Z