Here, we exposed Orbicella faveolata and Pseudodiploria clivosa genotypes to wild colonies showing signs consistent with stony coral tissue loss disease (SCTLD) immediately following a 2-month long exposure to ocean warming (OW) and ocean acidification (OA) scenarios. Corals were exposed to SCTLD for 3 weeks while maintaining the environmental treatments. This dataset is included in the OA-ICC data compilation maintained in the framework of the IAEA Ocean Acidification International Coordination Centre (see https://oa-icc.ipsl.fr). Original data were downloaded from Github (see Source) by the OA-ICC data curator. In order to allow full comparability with other ocean acidification data sets, the R package seacarb (Gattuso et al, 2024) was used to compute a complete and consistent set of carbonate system variables, as described by Nisumaa et al. (2010). In this dataset the original values were archived in addition with the recalculated parameters (see related PI). The date of carbonate chemistry calculation by seacarb is 2025-12-22.