Temperature dependent diffusion of water in human red blood cells

DOI

We propose to measure the diffusion of water in human red blood cells on the high resolution spectrometer IRIS with quasi-elastic neutron scattering. Diffusion of water in cells consist of a slow translational component and a fast rotational component. Due to the high energy resolution of IRIS we would be able to measure only the translational diffusion, the fast rotational diffusion would appear as flat background. Our aim is to show that there occurs a transition of translational water diffusion at human body temperature. To focus on water dynamics we intend to perform a difference experiment of red blood cells in H2O and D2O. As the incoherent scattering cross section of H is much bigger then D, we shall extract the dynamics of H2O by subtracting the intensity of scattered neutrons of the sample in D2O from that of the sample in H2O.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24003306
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24003306
Provenance
Creator Professor Georg Bueldt; Mr Andreas Stadler; Dr Joe Zaccai; Dr Ilja Digel; Professor Gerhard Artmann
Publisher ISIS Neutron and Muon Source
Publication Year 2011
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2008-04-21T09:51:01Z
Temporal Coverage End 2008-04-28T10:14:14Z